This proposal is submitted in response to RFA-ES-10-010, entitled """"""""Superfund Hazardous Substance Research and Training Program (P42)."""""""" The proposed work involves substantial work at the single most serious arsenic (As) Superfund site in Vineland, NJ. It also involves unique epidemiologic studies of As and Manganese (Mn)-exposed adults and adolescents residing in Bangladesh as well as an important mechanistic investigation of As-induced epigenetic dysregulation. As in the past, the Columbia University SRP Center includes a balance between biomedical and non-biomedical research. The proposal includes three biomedical research projects:1) Health Effects of As Longitudinal Study (HEALS);2) Consequences of As and Mn Exposure on Children's Health;and 3) Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation. The biomedical research is intimately intertwined with three nonbiomedical projects: 4) Arsenic, Iron, Sulfur and Organic Carbon Speciation, and Their Impact on Groundwater Arsenic;5) Application of Enhanced Mitigation Methods for Groundwater As at US Superfund Sites;and 6) Defining the Sustainable Uses of Low-As Aquifers in Bangladesh. The Projects are supported by four Research Support Core Laboratories: 8) Data Management;9) Trace Metals;10) Biogeochemistry;and 11) Hydrogeology. A Research Translation Core (RTC) entitled, """"""""Collaborating with government and the NIEHS SRP Center: As and Mn Exposure in Groundwater"""""""" works with several government agencies to help understand and solve their local groundwater problems. Finally, the RTC will work closely with the Community Engagement Core (CEC) entitled """"""""Promoting As Testing and Treatment to Reduce Health Risks for Residents in Maine."""""""" The CEC has developed naturally from our past biomedical and geochemical As research in Maine.

Public Health Relevance

The contamination of groundwater and soils with As and Mn are associated with major public health, remedial, and environmental policy problems. Both As and Mn are found at numerous Superfund sites. This competitive renewal proposal seeks to obtain fundamental new knowledge concerning the health effects, geochemistry, and remediation of As and Mn, with a particular focus on groundwater. Knowledge obtained from this research will have direct implications for remediation at contaminated sites and for the improvement of public health.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-JAB-J (SF))
Program Officer
Carlin, Danielle J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Public Health & Prev Medicine
Schools of Public Health
New York
United States
Zip Code
Wu, Fen; Chi, Liang; Ru, Hongyu et al. (2018) Arsenic Exposure from Drinking Water and Urinary Metabolomics: Associations and Long-Term Reproducibility in Bangladesh Adults. Environ Health Perspect 126:017005
Sanchez, Tiffany R; Powers, Martha; Perzanowski, Matthew et al. (2018) A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease? Curr Environ Health Rep 5:244-254
Farzan, Shohreh F; Howe, Caitlin G; Chen, Yu et al. (2018) Prenatal lead exposure and elevated blood pressure in children. Environ Int 121:1289-1296
Sanchez, Tiffany R; Slavkovich, Vesna; LoIacono, Nancy et al. (2018) Urinary metals and metal mixtures in Bangladesh: Exploring environmental sources in the Health Effects of Arsenic Longitudinal Study (HEALS). Environ Int 121:852-860
Spratlen, Miranda J; Grau-Perez, Maria; Umans, Jason G et al. (2018) Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study. Environ Int 121:728-740
Balakrishnan, Poojitha; Navas-Acien, Ana; Haack, Karin et al. (2018) Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Toxicol Appl Pharmacol 348:123-129
Oliver-Williams, Clare; Howard, Annie Green; Navas-Acien, Ana et al. (2018) Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians. J Am Soc Hypertens 12:426-437.e9
Jones, Miranda R; Tellez-Plaza, Maria; Vaidya, Dhananjay et al. (2018) Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA). J Expo Sci Environ Epidemiol :
Balakrishnan, Poojitha; Vaidya, Dhananjay; Voruganti, V Saroja et al. (2018) Genetic Variants Related to Cardiometabolic Traits Are Associated to B Cell Function, Insulin Resistance, and Diabetes Among AmeriCan Indians: The Strong Heart Family Study. Front Genet 9:466
Balakrishnan, Poojitha; Jones, Miranda R; Vaidya, Dhananjay et al. (2018) Ethnic, Geographic, and Genetic Differences in Arsenic Metabolism at Low Arsenic Exposure: A Preliminary Analysis in the Multi-Ethnic Study of Atherosclerosis (MESA). Int J Environ Res Public Health 15:

Showing the most recent 10 out of 333 publications