The major theme of this proposed Superfund Hazardous Substances Basic Research Program is the elucidation of mechanisms of exposure and toxicity in humans and ecosystems to particular Superfund chemicals selected based upon their potential significance with respect to developmental effects. The major goals of the Program are as follows: 1) to elucidate mechanisms of developmental toxicity of selected Superfund chemicals and chemical mixtures; 2) to facilitate the transfer of mechanistic information obtained across selected invertebrate and vertebrate models relevant to human and/or ecological health; 3) to utilize microarray approaches for assessing gene expression during normal and perturbed development in our models, and enhance the genomic database for these models; 4) to develop highly sensitive and efficient markers for developmental toxicities that can be incorporated into human health and ecological assessments; 5) to elucidate microbial and photolytic transformations of selected Superfund chemicals that augment their environmental fate and effects upon development; 6) to use Geographic Information Systems (GIS) spatial analysis to develop and disseminate preventive risk models for environmental health in North Carolina, with an emphasis on children; 7) to effectively deliver the Program's research results to critical members of the scientific, governmental, business and lay communities; and 8) to enhance interdisciplinary research, and graduate and post-graduate training, in the biomedical and environmental sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010356-08
Application #
7218721
Study Section
Special Emphasis Panel (ZES1-SET-A (S4))
Program Officer
Thompson, Claudia L
Project Start
2000-06-01
Project End
2009-03-31
Budget Start
2007-05-31
Budget End
2008-03-31
Support Year
8
Fiscal Year
2007
Total Cost
$2,371,915
Indirect Cost
Name
Duke University
Department
Type
Schools of Earth Sciences/Natur
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Oliveri, Anthony N; Ortiz, Erica; Levin, Edward D (2018) Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae. Neurotoxicol Teratol 67:25-30
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Rock, Kylie D; Horman, Brian; Phillips, Allison L et al. (2018) EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain. Endocr Connect 7:305-324

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