The goal of Project 4 is to elucidate the separate and combined effects of nanomaterial-based processes and microbial degradation on transformations of target Superfund chemicals, to better understand how nanomaterial-based remediation technologies might be best applied and, to achieve a maximum reduction in toxicity using combined nano-bio remediation. In addition, we seek to understand the potential impacts of nanomaterials themselves on the microbial ecology in sediments. The target contaminants for this study include an organophosphate insecticide (chlorpyrifos), a representative polycyclic aromatic hydrocarbon (benzo[a]pyrene), and a polybrominated flame retardant (decabrominated diphenyl ether, BDE-209). The pervasiveness of these compounds has resulted in a significant need for remediation-strategies to ameliorate their toxicity;however, care must be taken to ensure that remediation techniques do not result in increased toxicity or adverse effects from the use of the technology and/or the degradation products. This project studies remediation using zero valent iron (ZVI) and titanium dioxide (Ti02) nanomaterials for contaminant degradation. Our objectives are to: 1) Investigate the use of nanomaterials as catalysts for direct treatment of sediment and water contaminated by developmental toxicants;2) Assess microbial degradation of the target contaminants by sediment microorganisms with and without nanomaterials;and 3) Uncover possible synergies (or unintended antagonistic effects) of nanoparticle-based remediation with natural microbial degradation processes.
This project will provide guidance for the possible application of TiO2 or ZVI nanoparticles in remediating contaminated sites to achieve long-term degradation of targeted compounds through source treatment combined with in-situ natural attenuation, as well as treatment of dredged material.
|Meyer, Joel N; Hartman, Jessica H; Mello, Danielle F (2018) Mitochondrial Toxicity. Toxicol Sci 162:15-23|
|Oliveri, Anthony N; Ortiz, Erica; Levin, Edward D (2018) Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae. Neurotoxicol Teratol 67:25-30|
|Slotkin, Theodore A; Skavicus, Samantha; Seidler, Frederic J (2018) Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together. Toxicology 400-401:57-64|
|Lefèvre, Emilie; Bossa, Nathan; Gardner, Courtney M et al. (2018) Biochar and activated carbon act as promising amendments for promoting the microbial debromination of tetrabromobisphenol A. Water Res 128:102-110|
|Kollitz, Erin M; Kassotis, Christopher D; Hoffman, Kate et al. (2018) Chemical Mixtures Isolated from House Dust Disrupt Thyroid Receptor ? Signaling. Environ Sci Technol :|
|Hartman, Jessica H; Smith, Latasha L; Gordon, Kacy L et al. (2018) Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity. Sci Rep 8:8359|
|Luz, Anthony L; Kassotis, Christopher D; Stapleton, Heather M et al. (2018) The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPAR? activation, in 3T3-L1 cells. Toxicology 393:150-159|
|Day, D B; Xiang, J; Mo, J et al. (2018) Combined use of an electrostatic precipitator and a high-efficiency particulate air filter in building ventilation systems: Effects on cardiorespiratory health indicators in healthy adults. Indoor Air 28:360-372|
|Slotkin, Theodore A; Ko, Ashley; Seidler, Frederic J (2018) Does growth impairment underlie the adverse effects of dexamethasone on development of noradrenergic systems? Toxicology 408:11-21|
|Rock, Kylie D; Horman, Brian; Phillips, Allison L et al. (2018) EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain. Endocr Connect 7:305-324|
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