Data Management and Analysis Core (DMAC) The Data Management and Analysis Core (DMAC) is designed to enhance the LSU Superfund Research Program's (SRP?s) understanding of how environmentally persistent free radicals (EPFRs) induce pulmonary/cardiovascular dysfunction, and how to prevent formation, enhance decay, and limit exposure to EPFRs, with the ultimate goal of improving human health and the environment. The five Projects and supporting Cores in the LSU SRP present considerable data management and biostatistical challenges that are crucial to the overall success of the Center. The DMAC?s Specific Aims are to (1) Develop and implement a comprehensive data management plan for LSU SRP; (2) Develop and implement informatics solutions, including data collection, distribution, and analysis tools and secure storage for data generated by LSU SRP Projects and Cores; (3) Provide statistical expertise to SRP Projects and Cores; (4) Provide expertise in the application and development of novel statistical models and methodology for analysis of complex multidimensional data; (5) Provide educational initiatives and resources to serve a wide audience of graduate students, postdoctoral researchers, and junior faculty. DMAC members possess the knowledge, skills, and experiences necessary for tackling the complex multi-disciplinary issues to be addressed by the LSU SRP. We will implement a comprehensive data management strategy leveraging recent advances within the LSU system in high-speed computing and data distribution, along with stable and secure data collection, management, and storage platforms for facilitating multi-disciplinary collaborations. Our Core is committed to promoting transparent and reproducible research through the adoption of software, providing time-stamped version control over documents, files, and code, such as the Open Science Framework and the workflowr R package for statistical analysis. The DMAC biostatisticians will expand the toolsets available to the Superfund research community by developing novel approaches and methods for understanding the relationship between EPFR exposures and respiratory health effects using (multivariate) multiple mediation analysis, as well as the use of reliable machine learning methods for dimension reduction in the investigation of the microstructural pathway of EPFR formation and decay mechanisms, among other advancements. Last, the DMAC will develop and promote a wide array of initiatives in various formats and venues for educating SRP investigators, postdoctoral researchers, and graduate students on topics such as effective data management strategies, study design principles, and on conducting transparent, valid, generalizable, and repeatable research.

Public Health Relevance

Data Management and Analysis Core (DMAC) This Core will implement a comprehensive data management and analysis plan based on proven data capture, distribution, and storage technology, coupled with support from a highly experienced statistical team. Our integrated approach will facilitate collaborations among researchers using the rich datasets generated by SRP investigators and others to answer important questions of environmental and public health significance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES013648-08A1
Application #
9838932
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2020-02-01
Budget End
2021-01-31
Support Year
8
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Louisiana State University A&M Col Baton Rouge
Department
Type
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803
Hijano, Diego R; Siefker, David T; Shrestha, Bishwas et al. (2018) Type I Interferon Potentiates IgA Immunity to Respiratory Syncytial Virus Infection During Infancy. Sci Rep 8:11034
Haywood, Benjamin J; White, John R; Cook, Robert L (2018) Investigation of an early season river flood pulse: Carbon cycling in a subtropical estuary. Sci Total Environ 635:867-877
Connick, J Patrick; Reed, James R; Backes, Wayne L (2018) Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes. Drug Metab Dispos 46:197-203
Potter, Phillip M; Guan, Xia; Lomnicki, Slawomir M (2018) Synergy of iron and copper oxides in the catalytic formation of PCDD/Fs from 2-monochlorophenol. Chemosphere 203:96-103
Harmon, Ashlyn C; Hebert, Valeria Y; Cormier, Stephania A et al. (2018) Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithelial cells. PLoS One 13:e0205412
Jaligama, Sridhar; Patel, Vivek S; Wang, Pingli et al. (2018) Radical containing combustion derived particulate matter enhance pulmonary Th17 inflammation via the aryl hydrocarbon receptor. Part Fibre Toxicol 15:20
Dugas, Tammy R (2018) Unraveling mechanisms of toxicant-induced oxidative stress in cardiovascular disease. Curr Opin Toxicol 7:1-8
Jaligama, Sridhar; Saravia, Jordy; You, Dahui et al. (2017) Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter. Respir Res 18:15
Oyana, Tonny J; Lomnicki, Slawomir M; Guo, Chuqi et al. (2017) A Scalable Field Study Protocol and Rationale for Passive Ambient Air Sampling: A Spatial Phytosampling for Leaf Data Collection. Environ Sci Technol 51:10663-10673
Patterson, Matthew C; DiTusa, Mark F; McFerrin, Cheri A et al. (2017) Formation of environmentally persistent free radicals (EPFRs) on ZnO at room temperature: Implications for the fundamental model of EPFR generation. Chem Phys Lett 670:5-10

Showing the most recent 10 out of 108 publications