Abstract

While PCBs are semivolatile and commonly measured in air throughout the globe, atmospheric sources? of PCBs are almost completely undefined. This project will expand the knowledge of the sources and? distribution of PCBs in air through a major field study coupled with atmospheric modeling. The study is? structured as four aims:
Under Aim 1 we will determine the prevalence and distribution of atmospheric PCBs? in an urban area. We will monitor PCBs in air at select residential areas of Chicago, Illinois and East? Chicago, Indiana and compare results to Columbus Junction, Iowa.
Aim 1 will involve innovative methods in? sampling design, including high volume sampling from parked health clinic vans and passive sampling at? homes and schools. Over 1,000 air samples will be collected and analyzed for the full suite of PCB? congeners each year. The logistics of air sampling will be accomplished by cooperating with local health? agencies, schools, and governments. PCB congener analysis will be supported by a fully automated? analytical method for atmospheric PCB extraction, concentration, cleanup, analysis, and quality assurance.? Project Aims 2-4 focus on characterizing the sources using additional field measurements coupled with? mathematical modeling.
Aim 2 involves characterization of PCBs released from contaminated water. A field? and modeling study will examine the water of Indiana Harbor / Shipping Canal in East Chicago as an? emission source of PCBs.
Aim 3 concerns characterization of PCBs released from the soils of a former? refinery site destined to store PCB contaminated sediments.
Under Aim 4 we will evaluate mechanistic? models, dispersion models, and other computational models for estimating PCB emissions from other? (unknown) sources in the Chicago / East Chicago urban industrial region.
Aims 2 -4 include considerations? of the effects of season, local meteorology, topography, re-suspension of contaminated sediment,? construction activities at a contaminated site, and regional dispersion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES013661-02
Application #
7466422
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
2
Fiscal Year
2007
Total Cost
$280,069
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

P?n?íková, Kate?ina; Brenerová, Petra; Svržková, Lucie et al. (2018) Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25:16411-16419
Robertson, Larry W; Weber, Roland; Nakano, Takeshi et al. (2018) PCBs risk evaluation, environmental protection, and management: 50-year research and counting for elimination by 2028. Environ Sci Pollut Res Int 25:16269-16276
Klaren, William D; Vine, David; Vogt, Stefan et al. (2018) Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environ Sci Pollut Res Int 25:16427-16433
Tomsho, Kathryn S; Basra, Komal; Rubin, Staci M et al. (2018) Correction to: Community reporting of ambient air polychlorinated biphenyl concentrations near a Superfund site. Environ Sci Pollut Res Int 25:16401
Uwimana, Eric; Li, Xueshu; Lehmler, Hans-Joachim (2018) Human Liver Microsomes Atropselectively Metabolize 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite. Environ Sci Technol 52:6000-6008
Herkert, Nicholas J; Hornbuckle, Keri C (2018) Effects of room airflow on accurate determination of PUF-PAS sampling rates in the indoor environment. Environ Sci Process Impacts 20:757-766
Herkert, Nicholas J; Spak, Scott N; Smith, Austen et al. (2018) Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environ Sci Process Impacts 20:210-219
Dhakal, Kiran; Gadupudi, Gopi S; Lehmler, Hans-Joachim et al. (2018) Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290
Enayah, Sabah H; Vanle, Brigitte C; Fuortes, Laurence J et al. (2018) PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells. Toxicology 394:93-101
Klinefelter, Kelsey; Hooven, Molly Kromme; Bates, Chloe et al. (2018) Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome 29:112-127

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