Abstract

While PCBs are semivolatile and commonly measured in air throughout the globe, atmospheric sources? of PCBs are almost completely undefined. This project will expand the knowledge of the sources and? distribution of PCBs in air through a major field study coupled with atmospheric modeling. The study is? structured as four aims:
Under Aim 1 we will determine the prevalence and distribution of atmospheric PCBs? in an urban area. We will monitor PCBs in air at select residential areas of Chicago, Illinois and East? Chicago, Indiana and compare results to Columbus Junction, Iowa.
Aim 1 will involve innovative methods in? sampling design, including high volume sampling from parked health clinic vans and passive sampling at? homes and schools. Over 1,000 air samples will be collected and analyzed for the full suite of PCB? congeners each year. The logistics of air sampling will be accomplished by cooperating with local health? agencies, schools, and governments. PCB congener analysis will be supported by a fully automated? analytical method for atmospheric PCB extraction, concentration, cleanup, analysis, and quality assurance.? Project Aims 2-4 focus on characterizing the sources using additional field measurements coupled with? mathematical modeling.
Aim 2 involves characterization of PCBs released from contaminated water. A field? and modeling study will examine the water of Indiana Harbor / Shipping Canal in East Chicago as an? emission source of PCBs.
Aim 3 concerns characterization of PCBs released from the soils of a former? refinery site destined to store PCB contaminated sediments.
Under Aim 4 we will evaluate mechanistic? models, dispersion models, and other computational models for estimating PCB emissions from other? (unknown) sources in the Chicago / East Chicago urban industrial region.
Aims 2 -4 include considerations? of the effects of season, local meteorology, topography, re-suspension of contaminated sediment,? construction activities at a contaminated site, and regional dispersion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES013661-02
Application #
7466422
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
2
Fiscal Year
2007
Total Cost
$280,069
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Li, Xueshu; Holland, Erika B; Feng, Wei et al. (2018) Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environ Sci Pollut Res Int 25:16508-16521
Sethi, Sunjay; Keil, Kimberly P; Lein, Pamela J (2018) 3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Arch Toxicol 92:3337-3345
Parker, Victoria S; Squirewell, Edwin J; Lehmler, Hans-Joachim et al. (2018) Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1. Environ Toxicol Pharmacol 58:196-201
Mattes, Timothy E; Ewald, Jessica M; Liang, Yi et al. (2018) PCB dechlorination hotspots and reductive dehalogenase genes in sediments from a contaminated wastewater lagoon. Environ Sci Pollut Res Int 25:16376-16388
Uwimana, Eric; Ruiz, Patricia; Li, Xueshu et al. (2018) HUMAN CYP2A6, CYP2B6 AND CYP2E1 ATROPSELECTIVELY METABOLIZE POLYCHLORINATED BIPHENYLS TO HYDROXYLATED METABOLITES. Environ Sci Technol :
Rodriguez, Eric A; Vanle, Brigitte C; Doorn, Jonathan A et al. (2018) Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. Environ Toxicol Pharmacol 62:69-78
Hou, Xingwang; Yu, Miao; Liu, Aifeng et al. (2018) Biotransformation of tetrabromobisphenol A dimethyl ether back to tetrabromobisphenol A in whole pumpkin plants. Environ Pollut 241:331-338
Xiao, Xin; Chen, Baoliang; Chen, Zaiming et al. (2018) Insight into Multiple and Multilevel Structures of Biochars and Their Potential Environmental Applications: A Critical Review. Environ Sci Technol 52:5027-5047
Herkert, Nicholas J; Jahnke, Jacob C; Hornbuckle, Keri C (2018) Emissions of Tetrachlorobiphenyls (PCBs 47, 51, and 68) from Polymer Resin on Kitchen Cabinets as a Non-Aroclor Source to Residential Air. Environ Sci Technol 52:5154-5160
P?n?íková, Kate?ina; Svržková, Lucie; Strapá?ová, Simona et al. (2018) In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486

Showing the most recent 10 out of 298 publications