Project 4 ? Sources of Airborne PCBs Project 4 addresses SRP mandates for improved methods for detecting and assessing the hazards of Superfund chemicals. We will identify and characterize sources of airborne polychlorinated biphenyls (PCBs) within schools and homes, and near superfund sites with PCB-contaminated sediments. Sources of airborne PCBs may include building materials contaminated with legacy Aroclor PCBs, as well as consumer products that are inadvertently contaminated with PCBs through the manufacturing process. Our central hypothesis is that emissions of airborne PCBs are a function of the properties of the PCB congeners, environmental variables, and exposed surfaces in which the PCBs reside. We will examine all PCB congeners, and both Aroclor and non-Aroclor sources of airborne PCBs. We will evaluate emissions from materials and products found in schools and neighborhoods in our partner communities using methods that are accurate, precise, and reproducible. Data produced by Project 4 will enable cost-effective decisions for their removal. We will address Project 4?s central hypothesis by pursuing the following Specific Aims:
Aim 1 : We will develop novel passive sampling materials. We will design and manufacture tailored electrospun nanofiber mat (ENM) as an efficient and adaptable material for passive air sampling. We will design, calibrate, and deploy samplers equipped with this novel material to detect and measure PCB congeners in the environment.
Aim 2 : We will identify specific sources of airborne PCBs in schools and homes. ISRP research has already shown that building materials contaminated with Aroclors, and consumer products contaminated with non-Aroclor congeners, can contribute to high levels of PCBs in indoor air. We will measure airborne PCBs in schools and homes of Columbus Junction and West Liberty, Iowa; generate an inventory of potential sources in the school rooms; and measure emissions from those materials. We will also develop new laboratory methods to measure emissions and will apply computational fluid dynamics modeling of school rooms to determine the role of each material or consumer product as a source of airborne PCBs.
Aim 3 : We will characterize emissions from contaminated waters nation-wide. We hypothesize that contaminated waters are a major outdoor source of airborne PCB exposure nation-wide. We will use existing public data to predict emissions, dispersion, and annual median air concentrations in communities surrounding these waters. We will test our prediction through local measurements of airborne PCBs and communicate our findings to local communities and environmental protection officials, including the EPA. Our studies require close collaboration with the ISRP Analytical Core, Community Engagement Core, and Data Management and Analysis Core. Through these collaborations, Project 4 will provide strategies to prioritize technically and economically practical remediation options that focus on reduction of exposure to PCBs.
Project 4 ? Sources of Airborne PCBs The Iowa Superfund Research Program?s Project 4 addresses the problem of airborne PCBs in schools, in homes, and in communities near PCB-contaminated water. Researchers will identify specific sources of PCBs and the factors that cause these sources to release PCBs. Project 4 will provide essential and currently unavailable data and information needed to prioritize removal of these sources.
|Parker, Victoria S; Squirewell, Edwin J; Lehmler, Hans-Joachim et al. (2018) Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1. Environ Toxicol Pharmacol 58:196-201|
|Mattes, Timothy E; Ewald, Jessica M; Liang, Yi et al. (2018) PCB dechlorination hotspots and reductive dehalogenase genes in sediments from a contaminated wastewater lagoon. Environ Sci Pollut Res Int 25:16376-16388|
|Uwimana, Eric; Ruiz, Patricia; Li, Xueshu et al. (2018) HUMAN CYP2A6, CYP2B6 AND CYP2E1 ATROPSELECTIVELY METABOLIZE POLYCHLORINATED BIPHENYLS TO HYDROXYLATED METABOLITES. Environ Sci Technol :|
|Rodriguez, Eric A; Vanle, Brigitte C; Doorn, Jonathan A et al. (2018) Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. Environ Toxicol Pharmacol 62:69-78|
|Hou, Xingwang; Yu, Miao; Liu, Aifeng et al. (2018) Biotransformation of tetrabromobisphenol A dimethyl ether back to tetrabromobisphenol A in whole pumpkin plants. Environ Pollut 241:331-338|
|Xiao, Xin; Chen, Baoliang; Chen, Zaiming et al. (2018) Insight into Multiple and Multilevel Structures of Biochars and Their Potential Environmental Applications: A Critical Review. Environ Sci Technol 52:5027-5047|
|Herkert, Nicholas J; Jahnke, Jacob C; Hornbuckle, Keri C (2018) Emissions of Tetrachlorobiphenyls (PCBs 47, 51, and 68) from Polymer Resin on Kitchen Cabinets as a Non-Aroclor Source to Residential Air. Environ Sci Technol 52:5154-5160|
|P?n?íková, Kate?ina; Svržková, Lucie; Strapá?ová, Simona et al. (2018) In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486|
|P?n?íková, Kate?ina; Brenerová, Petra; Svržková, Lucie et al. (2018) Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25:16411-16419|
|Robertson, Larry W; Weber, Roland; Nakano, Takeshi et al. (2018) PCBs risk evaluation, environmental protection, and management: 50-year research and counting for elimination by 2028. Environ Sci Pollut Res Int 25:16269-16276|
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