Under this NIAAA Center grant The Scripps Research Institute Alcohol Research Center proposes to continue its long-term, cooperative interdisciplinary research program focused on the theme of the central nervous system effects of alcohol. For this renewal application, the TSRI- ARC will consist of 9 components. The Administrative Core resource (supervising six supporting resource units) and 7 independent collaborating research components as well as a separate Pilot Project Component are designed to stimulate new research directions and recruit new investigators to ethanol research. The TSRI-ARC research program remains strongly interdisciplinary, employing molecular, cellular, and cellular system and behavioral research methods on experimental animal subjects and human subjects. Three major subthemes emerging from our past 19 years of work within this Center will be continued: 1) the molecular, cellular, system mechanisms of the acute reinforcing actions of ethanol (intoxication) and its potential molecular, neurophysiologic, neuroendocrine, and behavioral concomitants (including reinforcing and aversive effects of acute intoxication, (Drs. Sanna, Gruol, Siggins, Henriksen, Rivier, and Weiss), 2) the molecular, cellular and system changes underlying the adaptive responses to the brain systems involve in ethanol reinforcement during alcohol dependence following chronic exposure (Drs. Sanna, Gruol, Siggins, Henriksen, Rivier, and Weiss, 3) the molecular, cellular and neuropsychological basis for susceptibility to alcohol dependence and relapse in humans (Drs. Sanna, Gruol, Siggins, Henriksen, Rivier, Weiss, Ehlers and Polich). Progress during the previous funding period including new advances in animal model development have lead to a focusing of the new proposed work to understanding the neurobiology of ethanol dependence and relapse (subthemes 2 and 3). Individual research components range from studies of the effects of chronic ethanol on neuroadaptive mechanisms involving neuronal transduction mechanisms at the cellular, neuroendocrine and neurobehavioral levels to clinical studies of vulnerability to dependence. The TSRI-ARC also supports 11 RO1, R20, R29, and U10 grants of the TSRI- ARC PIs, and other major alcohol research groups at the UCSD VA Medical Center and San Diego State University through the collaboration, training and information exchange of the Administrative Core Support Units. Research funded within this Center provides the basic research knowledge required from development of better understanding of the basis for susceptibility to alcoholism important for new treatments and prevention.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Specialized Center (P50)
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Health Services Research Review Subcommittee (AA)
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Vanderveen, Ernestine
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Scripps Research Institute
La Jolla
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Kononoff, Jenni; Melas, Philippe A; Kallupi, Marsida et al. (2018) Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep 8:13893
Verheij, Michel M M; Contet, Candice; Karel, Peter et al. (2018) Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biol Psychiatry 83:1024-1035
Takashima, Yoshio; Mandyam, Chitra D (2018) The role of hippocampal adult neurogenesis in methamphetamine addiction. Brain Plast 3:157-168
Takashima, Yoshio; Fannon, McKenzie J; Galinato, Melissa H et al. (2018) Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking. Brain Struct Funct 223:2197-2211
Berger, Anthony L; Henricks, Angela M; Lugo, Janelle M et al. (2018) The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System. Biol Psychiatry 84:611-623
Galinato, Melissa H; Takashima, Yoshio; Fannon, McKenzie J et al. (2018) Neurogenesis during Abstinence Is Necessary for Context-Driven Methamphetamine-Related Memory. J Neurosci 38:2029-2042
Ehlers, Cindy L; Wills, Derek; Gilder, David A (2018) A history of binge drinking during adolescence is associated with poorer sleep quality in young adult Mexican Americans and American Indians. Psychopharmacology (Berl) 235:1775-1782
Serrano, Antonia; Pavon, Francisco J; Buczynski, Matthew W et al. (2018) Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. Neuropsychopharmacology 43:1840-1850
Kirson, Dean; Oleata, Christopher Shaun; Parsons, Loren Howell et al. (2018) CB1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats. Addict Biol 23:676-688
Fannon, McKenzie J; Mysore, Karthik K; Williams, Jefferson et al. (2018) Hippocampal neural progenitor cells play a distinct role in fear memory retrieval in male and female CIE rats. Neuropharmacology 143:239-249

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