Prevention of alcohol abuse during pregnancy is the only known method of preventing alcohol related birth defects and developmental deficits. This research is designed to ascertain the impact of an intensive alcohol abuse prevention program on 1) infant outcome (Bayley at 12 months as well as birth weight, gestational age, ARBDs) and 2) reported maternal drinking, using a randomized clinical trial. We will focus on a high risk population of black women who report moderate to heavy periconceptional drinking. The intervention program is preconceptional, focusing on preventing heavy drinking during the next pregnancy. The randomized clinical trial design randomly assigns postpartum women immediately after they deliver their """"""""index"""""""" child to 1) a control group, which will receive the standard alcohol abuse prevention program or 2) an experimental group, which will receive an intensive alcohol abuse prevention program. The women will be followed for up to three years through the conception and delivery of their next child. The primary hypothesis to be tested is the subsequent child born to the mother in the experimental group will have better Bayley scores than the mother's index child. Secondary hypotheses include comparisons within groups (index versus subsequent) and between groups (subsequent experimental versus subsequent control) on maternal and child outcome measures. The study will take place during the entire five years of the center.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
3P50AA007606-10S1
Application #
6097671
Study Section
Project Start
1998-05-01
Project End
1998-11-30
Budget Start
Budget End
Support Year
10
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Dodge, Neil C; Jacobson, Joseph L; Jacobson, Sandra W (2014) Protective effects of the alcohol dehydrogenase-ADH1B*3 allele on attention and behavior problems in adolescents exposed to alcohol during pregnancy. Neurotoxicol Teratol 41:43-50
Jacobson, Sandra W; Carter, R Colin; Jacobson, Joseph L (2014) Breastfeeding as a proxy for benefits of parenting skills for later reading readiness and cognitive competence. J Pediatr 164:440-2
Carter, R Colin; Jacobson, Joseph L; Dodge, Neil C et al. (2014) Effects of prenatal alcohol exposure on testosterone and pubertal development. Alcohol Clin Exp Res 38:1671-9
Yumoto, Chie; Jacobson, Sandra W; Jacobson, Joseph L (2008) Fetal substance exposure and cumulative environmental risk in an African American cohort. Child Dev 79:1761-76
Cortese, Bernadette M; Moore, Gregory J; Bailey, Beth A et al. (2006) Magnetic resonance and spectroscopic imaging in prenatal alcohol-exposed children: preliminary findings in the caudate nucleus. Neurotoxicol Teratol 28:597-606
Jacobson, Sandra W; Carr, Lucinda G; Croxford, Julie et al. (2006) Protective effects of the alcohol dehydrogenase-ADH1B allele in children exposed to alcohol during pregnancy. J Pediatr 148:30-7
Burden, Matthew J; Jacobson, Sandra W; Jacobson, Joseph L (2005) Relation of prenatal alcohol exposure to cognitive processing speed and efficiency in childhood. Alcohol Clin Exp Res 29:1473-83
Burden, Matthew J; Jacobson, Sandra W; Sokol, Robert J et al. (2005) Effects of prenatal alcohol exposure on attention and working memory at 7.5 years of age. Alcohol Clin Exp Res 29:443-52
Jacobson, Sandra W; Jacobson, Joseph L; Sokol, Robert J et al. (2004) Maternal age, alcohol abuse history, and quality of parenting as moderators of the effects of prenatal alcohol exposure on 7.5-year intellectual function. Alcohol Clin Exp Res 28:1732-45
Das, Utpala G; Cronk, Christine E; Martier, Susan S et al. (2004) Alcohol dehydrogenase 2*3 affects alterations in offspring facial morphology associated with maternal ethanol intake in pregnancy. Alcohol Clin Exp Res 28:1598-606

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