Abstract

The proposed project is aimed at establishing a biologic specimen bank as an element of three of the scientific research components in this application. The biological bank will be composed of frozen specimens (plasma, serum, cells, cell membranes, urine) from randomly-selected black and white men and women age 35-79, controls in the two case-control studies on myocardial infarction and lung cancer, cases from the two case-control studies, and participants in the research component on the epidemiology of treated and untreated alcoholics. Blood samples from a total of 7,520 men and women will be stored. The establishment of a biological specimen bank will allow us to complement and potentiate the usefulness of the other research components because it will allow for the possibility of studies continuing beyond the timeframe of the proposed research projects. The establishment of a biologic specimen bank as part of the ongoing research activities could be, therefore, and extremely valuable way to expand the importance of the proposed research project in a valid and economical way.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA009802-03
Application #
5204282
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Ricks-Santi, Luisel; McDonald, J Tyson; Gold, Bert et al. (2017) Next Generation Sequencing Reveals High Prevalence of BRCA1 and BRCA2 Variants of Unknown Significance in Early-Onset Breast Cancer in African American Women. Ethn Dis 27:169-178
Kranjac, Ashley Wendell; Nie, Jing; Trevisan, Maurizio et al. (2017) Depression and body mass index, differences by education: Evidence from a population-based study of adult women in the U.S. Buffalo-Niagara region. Obes Res Clin Pract 11:63-71
Tao, Meng-Hua; Dai, Qi; Millen, Amy E et al. (2016) Associations of intakes of magnesium and calcium and survival among women with breast cancer: results from Western New York Exposures and Breast Cancer (WEB) Study. Am J Cancer Res 6:105-13
Ochs-Balcom, Heather M; Marian, Catalin; Nie, Jing et al. (2015) Adiposity is associated with p53 gene mutations in breast cancer. Breast Cancer Res Treat 153:635-45
Ochs-Balcom, Heather M; Lainhart, William; Mnatsakanova, Anna et al. (2013) The association of depressive symptoms and pulmonary function in healthy adults. Psychosom Med 75:737-43
Tao, Meng-Hua; Hainaut, Pierre; Marian, Catalin et al. (2013) Association of prediagnostic physical activity with survival following breast cancer diagnosis: influence of TP53 mutation status. Cancer Causes Control 24:2177-86
Ricks-Santi, Luisel J; Nie, Jing; Marian, Catalin et al. (2013) BRCA1 polymorphisms and breast cancer epidemiology in the Western New York exposures and breast cancer (WEB) study. Genet Epidemiol 37:504-11
Tao, M-H; Marian, C; Shields, P G et al. (2013) Exposures in early life: associations with DNA promoter methylation in breast tumors. J Dev Orig Health Dis 4:182-90
Weaver, Anne M; McCann, Susan E; Nie, Jing et al. (2013) Alcohol intake over the life course and breast cancer survival in Western New York exposures and breast cancer (WEB) study: quantity and intensity of intake. Breast Cancer Res Treat 139:245-53
Li, Yanli; Nie, Jing; Beyea, Jan et al. (2013) Exposure to traffic emissions: associations with biomarkers of antioxidant status and oxidative damage. Environ Res 121:31-8

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