Abstract

Acute ethanol exposure impairs learning and memory in humans and laboratory animals. Ethanol-induced deficits in spatial memory are believed to involved a suppression of hippocampal neuroplasticity. This pilot project examines spatial memory, spatial firing patterns of hippocampal neurons, and their sensitivity to acute ethanol, across inbred strains of mice. Two types of hippocampal neurons exhibit firing rates that are influenced by spatial information, location (place cells) and direction (head direction (HD) cells). The place and HD cell signals are thought to support spatial memory.
Specific Aim 1 examines hippocampal-dependent spatial memory and its sensitivity to ethanol in five inbred strains of mice. Specific examine hippocampal-dependent spatial memory and its sensitivity to ethanol in five inbred strains of mice.
Specific Aim 2 examines the spatial firing properties of place and HD cells and the influence of ethanol in the same inbred mouse strains. Amnestic doses of ethanol (from Aim 1) are predicted to influence spatial firing of place and HD cells. This research examines hippocampal functional cross inbred strains of mice and examines whether sensitivity to the behavioral effects of ethanol includes ethanol-induced amnesia. The goal of this project is to generate preliminary data for an R01 application to support research on the cognitive and neurophysiological effects of acute ethanol in inbred mouse strains.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
2P50AA010760-06
Application #
6434274
Study Section
Special Emphasis Panel (ZAA1)
Project Start
1995-12-20
Project End
2005-12-31
Budget Start
Budget End
Support Year
6
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Iancu, Ovidiu D; Colville, Alexander; Walter, Nicole A R et al. (2018) On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome. Addict Biol 23:196-205
Purohit, Kush; Parekh, Puja K; Kern, Joseph et al. (2018) Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge-Like Alcohol Drinking in Mice. Alcohol Clin Exp Res 42:879-888
Iancu, Ovidiu Dan; Colville, Alex M; Wilmot, Beth et al. (2018) Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs. Alcohol Clin Exp Res :
Aoun, E G; Jimenez, V A; Vendruscolo, L F et al. (2018) A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans. Mol Psychiatry 23:1466-1473
Buck, Kari J; Chen, Gang; Kozell, Laura B (2017) Limbic circuitry activation in ethanol withdrawal is regulated by a chromosome 1 locus. Alcohol 58:153-160
Crabbe, John C; Ozburn, Angela R; Metten, Pamela et al. (2017) High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking. Pharmacol Biochem Behav 160:55-62
Colville, A M; Iancu, O D; Oberbeck, D L et al. (2017) Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice. Genes Brain Behav 16:462-471
Hitzemann, Robert; Oberbeck, Denesa; Iancu, Ovidiu et al. (2017) Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID). Alcohol 60:115-120
Crabbe, John C (2016) Progress With Nonhuman Animal Models of Addiction. J Stud Alcohol Drugs 77:696-9
Barkley-Levenson, Amanda M; Ryabinin, Andrey E; Crabbe, John C (2016) Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication. Behav Brain Res 302:160-70

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