The Shared Core provides centralized services needed by investigators in the Charleston Alcohol Research Center (ARC). Since its inception, the Shared Core has been a valuable part of the ARC, achieving its goals and refining its services to best meet the needs of a dynamic research environment. The proposed Shared Core contains two new services identified as important by Center researchers, the Animal Model Core and the Genotyping Core, while retaining the highly valued and widely utilized Biostatistics Core. - The Animal Model Core will provide basic science researchers in the Center with mice that have been treated in a standardized, well-validated ethanol dependence model. This will facilitate integration of data collected from the various Center projects including electrophysiological, neurochemical, and behavioral measures that will be related to consequences of chronic intermittent ethanol exposure using a single model. - The Genotyping Core will support the Center's increasing needs for advanced genetic analysis. Although this service will predominantly support clinical research projects in the ARC, extending this core function to other clinical as well as preclinical projects will enhance translational efforts in the Center. - The Biostatistics Core will continue to provide data management and expert statistical analysis and consulting service to all Center research projects through the Office of Statistics and Database Management. By centralizing these services, several important benefits are realized. First, the Shared Core provides needed expertise in specialized areas. Second, it affords a more efficient and standardized research environment, as it prevents the duplication of effort by individual research groups. Third, the Shared Core provides time- and cost-savings for all research studies that utilize the services. Finally, the Shared Core system fosters greater integration of Center research activities and it provides a central authority for quality control over provision and utilization of services as well as ensuring that its services meet the needs of Center investigators.

Public Health Relevance

The Shared Core contains the Animal Model Core, Genotyping Core, and Biostatistics Core and provides these valuable services to all research components and pilot projects in the Charleston ARC. By centralizing these services, the Shared Core promotes integrative, efficient, and high quality research activities that facilitate the Center in successfully meeting its overall research goals and mission.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA010761-19
Application #
8601284
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Type
DUNS #
City
Charleston
State
SC
Country
United States
Zip Code
29403
Zamudio-Bulcock, Paula A; Homanics, Gregg E; Woodward, John J (2018) Loss of Ethanol Inhibition of N-Methyl-D-Aspartate Receptor-Mediated Currents and Plasticity of Cerebellar Synapses in Mice Expressing the GluN1(F639A) Subunit. Alcohol Clin Exp Res 42:698-705
Cannady, Reginald; Rinker, Jennifer A; Nimitvilai, Sudarat et al. (2018) Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior. Handb Exp Pharmacol 248:311
Harlan, Benjamin A; Becker, Howard C; Woodward, John J et al. (2018) Opposing actions of CRF-R1 and CB1 receptors on VTA-GABAergic plasticity following chronic exposure to ethanol. Neuropsychopharmacology 43:2064-2074
Hanlon, Colleen A; Dowdle, Logan T; Henderson, J Scott (2018) Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development. Pharmacol Rev 70:661-683
Hanlon, Colleen A; Dowdle, Logan T; Gibson, Nicole B et al. (2018) Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex. Transl Psychiatry 8:186
Gioia, Dominic A; Xu, Minfu; Wayman, Wesley N et al. (2018) Effects of drugs of abuse on channelrhodopsin-2 function. Neuropharmacology 135:316-327
Anton, Raymond F; Latham, Patricia K; Voronin, Konstantin E et al. (2018) Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence. Alcohol Clin Exp Res 42:751-760
Anderson, Ethan M; Larson, Erin B; Guzman, Daniel et al. (2018) Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety. J Neurosci 38:803-813
Osterndorff-Kahanek, Elizabeth A; Tiwari, Gayatri R; Lopez, Marcelo F et al. (2018) Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. PLoS One 13:e0190841
Stewart, Scott H; Reuben, Adrian; Anton, Raymond F (2018) Reply: Carbohydrate Deficient Transferrin in Patients with Cirrhosis: A Tale of Bridges. Alcohol Alcohol 53:351-352

Showing the most recent 10 out of 209 publications