The Shared Resource Core provides centralized resources and services that are tailored to the research needs of investigators in the Charleston Alcohol Research Center (ARC). In doing so, the Shared Resource Core continues to serve the critical role of promoting scientific integration, increasing efficient use of resources, and facilitating use of high quality contemporary technological and investigatory approaches that, collectively, are key to meeting the dynamic research environment fostered by the ARC. The Shared Resource Core is comprised of the Animal Core, the Clinical Intake and Assessment Core, and the Biostatistics Core. The Animal Core provides basic research projects and pilot projects with animals treated in a well-validated and established mouse model of alcohol dependence that involves repeated cycles of chronic intermittent ethanol (CIE) exposure. The Animal Core also will execute stereotaxic surgery and histological evaluation functions to support research incorporating direct brain site-specific injections of pharmacological agents, retrograde tracers, and viral vectors for optogenetic and pharmacosynthetic manipulations. The Clinical Intake and Assessment Core will expand current genotyping work to centralize advertisement and recruitment efforts, perform initial screening of potential study participants, and utilize assessment procedures (including genotyping) to best match and optimize allocation of subjects for enrollment in clinical research projects and pilot projects in the Center. The Biostatistics Core will continue to provide data management and statistical service to both basic and clinical research projects and pilots in the Center. This includes assisting in study design development, performing power analyses at the front end of the projects, construction of appropriate databases, conducting analyses utilizing various contemporary statistical approaches, and assisting in preparation of manuscripts and presentations for dissemination of study results. By centralizing these vital scientific functions, the Core avoids duplication of efforts, increases efficient use of resources, facilitates use of state-of-the-art research approaches and techniques, and improves quality control through oversight of centralized functions - all contributing to maximizing productivity in the ARC. Overall, the Shared Resource Core plays a pivotal role in enhancing integration and cohesion of ARC research activities, as well as stimulating and supporting the vibrant alcohol research and training environment at MUSC.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
United States
Zip Code
Gioia, Dominic A; Xu, Minfu; Wayman, Wesley N et al. (2018) Effects of drugs of abuse on channelrhodopsin-2 function. Neuropharmacology 135:316-327
Anton, Raymond F; Latham, Patricia K; Voronin, Konstantin E et al. (2018) Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence. Alcohol Clin Exp Res 42:751-760
Anderson, Ethan M; Larson, Erin B; Guzman, Daniel et al. (2018) Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety. J Neurosci 38:803-813
Osterndorff-Kahanek, Elizabeth A; Tiwari, Gayatri R; Lopez, Marcelo F et al. (2018) Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. PLoS One 13:e0190841
Stewart, Scott H; Reuben, Adrian; Anton, Raymond F (2018) Reply: Carbohydrate Deficient Transferrin in Patients with Cirrhosis: A Tale of Bridges. Alcohol Alcohol 53:351-352
Kearney-Ramos, Tonisha E; Lench, Daniel H; Hoffman, Michaela et al. (2018) Gray and white matter integrity influence TMS signal propagation: a multimodal evaluation in cocaine-dependent individuals. Sci Rep 8:3253
Haun, Harold L; Griffin, William C; Lopez, Marcelo F et al. (2018) Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice. Neuropharmacology 140:35-42
Schacht, Joseph P; Voronin, Konstantin E; Randall, Patrick K et al. (2018) Dopaminergic Genetic Variation Influences Aripiprazole Effects on Alcohol Self-Administration and the Neural Response to Alcohol Cues in a Randomized Trial. Neuropsychopharmacology 43:1247-1256
McGuier, Natalie S; Rinker, Jennifer A; Cannady, Reginald et al. (2018) Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents. Neuropharmacology 138:10-19
Nimitvilai, Sudarat; Lopez, Marcelo F; Woodward, John J (2018) Effects of monoamines on the intrinsic excitability of lateral orbitofrontal cortex neurons in alcohol-dependent and non-dependent female mice. Neuropharmacology 137:1-12

Showing the most recent 10 out of 209 publications