The Shared Resource Core provides centralized resources and services that are tailored to the research needs of investigators in the Charleston Alcohol Research Center (ARC). In doing so, the Shared Resource Core continues to serve the critical role of promoting scientific integration, increasing efficient use of resources, and facilitating use of high quality contemporary technological and investigatory approaches that, collectively, are key to meeting the dynamic research environment fostered by the ARC. The Shared Resource Core is comprised of the Animal Core, the Clinical Intake and Assessment Core, and the Biostatistics Core. The Animal Core provides basic research projects and pilot projects with animals treated in a well-validated and established mouse model of alcohol dependence that involves repeated cycles of chronic intermittent ethanol (CIE) exposure. The Animal Core also will execute stereotaxic surgery and histological evaluation functions to support research incorporating direct brain site-specific injections of pharmacological agents, retrograde tracers, and viral vectors for optogenetic and pharmacosynthetic manipulations. The Clinical Intake and Assessment Core will expand current genotyping work to centralize advertisement and recruitment efforts, perform initial screening of potential study participants, and utilize assessment procedures (including genotyping) to best match and optimize allocation of subjects for enrollment in clinical research projects and pilot projects in the Center. The Biostatistics Core will continue to provide data management and statistical service to both basic and clinical research projects and pilots in the Center. This includes assisting in study design development, performing power analyses at the front end of the projects, construction of appropriate databases, conducting analyses utilizing various contemporary statistical approaches, and assisting in preparation of manuscripts and presentations for dissemination of study results. By centralizing these vital scientific functions, the Core avoids duplication of efforts, increases efficient use of resources, facilitates use of state-of-the-art research approaches and techniques, and improves quality control through oversight of centralized functions - all contributing to maximizing productivity in the ARC. Overall, the Shared Resource Core plays a pivotal role in enhancing integration and cohesion of ARC research activities, as well as stimulating and supporting the vibrant alcohol research and training environment at MUSC.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA010761-25
Application #
9843629
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2020-01-01
Budget End
2020-12-31
Support Year
25
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29407
Haun, Harold L; Griffin, William C; Lopez, Marcelo F et al. (2018) Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice. Neuropharmacology 140:35-42
Schacht, Joseph P; Voronin, Konstantin E; Randall, Patrick K et al. (2018) Dopaminergic Genetic Variation Influences Aripiprazole Effects on Alcohol Self-Administration and the Neural Response to Alcohol Cues in a Randomized Trial. Neuropsychopharmacology 43:1247-1256
McGuier, Natalie S; Rinker, Jennifer A; Cannady, Reginald et al. (2018) Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents. Neuropharmacology 138:10-19
Nimitvilai, Sudarat; Lopez, Marcelo F; Woodward, John J (2018) Effects of monoamines on the intrinsic excitability of lateral orbitofrontal cortex neurons in alcohol-dependent and non-dependent female mice. Neuropharmacology 137:1-12
Dowdle, Logan T; Brown, Truman R; George, Mark S et al. (2018) Single pulse TMS to the DLPFC, compared to a matched sham control, induces a direct, causal increase in caudate, cingulate, and thalamic BOLD signal. Brain Stimul 11:789-796
Zamudio-Bulcock, Paula A; Homanics, Gregg E; Woodward, John J (2018) Loss of Ethanol Inhibition of N-Methyl-D-Aspartate Receptor-Mediated Currents and Plasticity of Cerebellar Synapses in Mice Expressing the GluN1(F639A) Subunit. Alcohol Clin Exp Res 42:698-705
Cannady, Reginald; Rinker, Jennifer A; Nimitvilai, Sudarat et al. (2018) Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior. Handb Exp Pharmacol 248:311
Harlan, Benjamin A; Becker, Howard C; Woodward, John J et al. (2018) Opposing actions of CRF-R1 and CB1 receptors on VTA-GABAergic plasticity following chronic exposure to ethanol. Neuropsychopharmacology 43:2064-2074
Hanlon, Colleen A; Dowdle, Logan T; Henderson, J Scott (2018) Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development. Pharmacol Rev 70:661-683
Hanlon, Colleen A; Dowdle, Logan T; Gibson, Nicole B et al. (2018) Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex. Transl Psychiatry 8:186

Showing the most recent 10 out of 209 publications