Alcoholic liver and pancreatic diseases (ALPD) and cirrhosis constitute leading life-style diseases around the globe. The Southern California Research Center for ALPD and Cirrhosis unifies 57 investigators from major academic institutions in Southern California to pursue a common mission of being a leader in research, training, and outreach for the diseases. The center, since its inception in 1999, has devoted its efforts for development and use of clinically relevant animal models to gain novel insights into the molecular mechanisms underlying the predisposition to advanced ALPD. These efforts culminated to recent groundbreaking discoveries which have significantly advanced our understanding of synergistic ALPD caused by alcohol and a second hit. The center's interactive environment and infrastructure have facilitated in the past 5 years, a 152% increase in research base to $8.5M/year;4 new UOl/POI programs;198 publications;generation of 14 NIH-funded early-stage investigators;transition of 8 postdocs to faculty positions;training 166 graduate and 20 undergraduate students;and organizing 3 community seminars and 4 international symposia. As a unique national resource, the center has provided to scientific communities across the nation: 229 rodents as ALPD models and 241 model samples for 17 outside investigators;329 liver cell isolation preparations for 14 investigators;and support for grant acquisition and application by 12 outside investigators since the last renewal. The center will continue to strive as a unique scientific center of excellence in ALPD and cirrhosis by promoting: 1) environment conducive for leading-edge research on the center's theme: elucidation of the priming and sensitizing mechanisms for ALPD;2) provision of unique models, innovative genetic approaches and expertise to outside investigators including those at other NIAAA Alcohol Research Centers;3) comprehensive education and training to foster future generations of scientists in ALPD and cirrhosis;and 4) outreach efforts to disseminate the center's new findings to lay public, health care workers and scientists in our home and global communities.

Public Health Relevance

ALPD and cirrhosis are the major medical consequences of alcohol abuse and prevalent life-style diseases around the world. Our center's consorted efforts for research, training, and dissemination, and the outcome from these activities help advance the understanding of the diseases and develop novel preventive and therapeutic approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
2P50AA011999-16
Application #
8590794
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Gao, Peter
Project Start
1999-01-01
Project End
2018-12-31
Budget Start
2014-02-01
Budget End
2014-12-31
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Southern California
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Wu, Raymond; Murali, Ramachandran; Kabe, Yasuaki et al. (2018) Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition. Hepatology 68:1726-1740
Buxbaum, James; Quezada, Michael; Chong, Bradford et al. (2018) The Pancreatitis Activity Scoring System predicts clinical outcomes in acute pancreatitis: findings from a prospective cohort study. Am J Gastroenterol 113:755-764
Zhao, Qinglan; Wei, Yi; Pandol, Stephen J et al. (2018) STING Signaling Promotes Inflammation in Experimental Acute Pancreatitis. Gastroenterology 154:1822-1835.e2
Edderkaoui, Mouad; Chheda, Chintan; Soufi, Badr et al. (2018) An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice. Gastroenterology 155:1985-1998.e5
Khanova, Elena; Wu, Raymond; Wang, Wen et al. (2018) Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology 67:1737-1753
Zheng, Han; You, Yang; Hua, Meiyun et al. (2018) Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice. Front Physiol 9:1671
Lew, Daniel; Wu, Bechien U; Pandol, Stephen J et al. (2018) Disease Course Differences in Acute Pancreatitis Based on Etiology Using the Pancreatitis Activity Scoring System. Pancreas 47:e40-e41
Ogawa, Tomohiro; Li, Yuchang; Lua, Ingrid et al. (2018) Isolation of a unique hepatic stellate cell population expressing integrin ?8 from embryonic mouse livers. Dev Dyn 247:867-881
Tripathi, Anupriya; Debelius, Justine; Brenner, David A et al. (2018) The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15:397-411
Waldron, Richard T; Su, Hsin-Yuan; Piplani, Honit et al. (2018) Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. Cell Mol Gastroenterol Hepatol 5:479-497

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