Alcoholic liver and pancreatic diseases (ALPD) and cirrhosis constitute leading life-style diseases caused by alcohol abuse around the globe. The Southern California Research Center for ALPD and Cirrhosis unifies 58 investigators from seven academic institutions in Southern California to pursue a common mission of being a leader in research, training, and outreach for the diseases. The center, since its inception in 1999, has devoted its efforts for development and use of clinically relevant animal models to gain novel insights into the molecular mechanisms underlying ALPD and cirrhosis. These efforts culminated to groundbreaking discoveries on molecular mechanisms and therapeutic targets of the diseases. The center?s interactive environment and infrastructure have facilitated in the past 5 years, a 187% increase in research base to $16.3M/year; 13 new U01/P01 programs; 219 publications; generation of 12 NIH-funded early-stage investigators; 8 of 15 postdocs transitioned to faculty positions pursuing research at the center; training 179 graduate and 38 undergraduate students; and organizing 2 community seminars and 4 international symposia. As a unique national resource, the center has supported 34 non-center member investigators; 13 of whom via provision of animal model services of the Animal Core; and 27 of whom via the Core?s Tissue Sharing Program, facilitating 13 publications and 15 grant acquisitions and applications by these investigators. The center will continue to strive as a unique scientific center of excellence in ALPD and cirrhosis by: 1) maximizing our interactive and synergistic environment for a pursuit for the center?s main research theme: identification of therapeutic targets for advanced ALPD and cirrhosis; 2) serving as a national and international resource in our fields of research via provision of unique models, technology and expertise, as well as collaborations with outside investigators including NIAAA-funded scientists; 3) providing comprehensive education and research training at the multi-levels ranging from undergraduate and graduate students, postdoctoral trainees, to junior scientists and faculty in order to foster and support future generations of independent scientists in the ALPD and cirrhosis field; and 4) continuing outreach efforts to disseminate the center?s new findings to lay public, healthcare workers, and scientists in our home and global communities.

Public Health Relevance

OVERALL - NARRATIVE ALPD and cirrhosis are the major medical consequences of alcohol abuse and prevalent life- style diseases around the world. Our center's consorted efforts for research, training, and dissemination, and the outcome from these activities help advance the understanding of the diseases and develop novel preventive and therapeutic approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA011999-23
Application #
10077252
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Gao, Peter
Project Start
1999-01-01
Project End
2023-12-31
Budget Start
2021-01-01
Budget End
2021-12-31
Support Year
23
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Southern California
Department
Pathology
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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Khanova, Elena; Wu, Raymond; Wang, Wen et al. (2018) Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology 67:1737-1753
Zheng, Han; You, Yang; Hua, Meiyun et al. (2018) Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice. Front Physiol 9:1671
Lew, Daniel; Wu, Bechien U; Pandol, Stephen J et al. (2018) Disease Course Differences in Acute Pancreatitis Based on Etiology Using the Pancreatitis Activity Scoring System. Pancreas 47:e40-e41
Ogawa, Tomohiro; Li, Yuchang; Lua, Ingrid et al. (2018) Isolation of a unique hepatic stellate cell population expressing integrin ?8 from embryonic mouse livers. Dev Dyn 247:867-881

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