The goal of the Molecular Core are to consolidate a range of molecular biological and molecular genetic methods that are required for several of the CTNA projects and pilot studies. The rationale for this core is both scientific and practical. From the scientific perspective, it makes sense to place these methodologies under a single entity to ensure that state-of- the-art techniques and approaches are used. For example, the Core will ensure that genotyping strategies used for clinical samples and for transgenic mice both take advantage of the most accurate and high throughput approaches available, not only now but also over the five year course of the grant. From the practical perspective, pacing these technologies within a single Core increases efficiencies and economy of scale, thereby deriving considerable savings for the overall CTNA. With Dr. Nestler serving as Director of the Core and Dr. Gelernter serving as Co-Director, the Core provides a concrete vehicle of interaction between genetic studies in mice and humans that are supported by the CTNA. Thus, the Core bolsters the translational nature of the proposed studies, which is a major defining feature of the CTNA proposal. 1. Animal genetic studies: To breed and genotype several lines of inducible, tissue-specific transgenic mice that support the expression of transcription within brain regions of interest. 2. Human genetic studies: To type closely-spaced short tandem repeat (STR) markers in regions identified in previous genome studies (COGA, NIAAA) as potentially linked to alcohol dependence, and to then screen for mutations that potentially affect the function of candidate genes that map to linkage disequilibrium regions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
1P50AA012870-01
Application #
6544164
Study Section
Special Emphasis Panel (ZAA1)
Project Start
2001-06-04
Project End
2006-05-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Morean, Meghan E; DeMartini, Kelly S; Foster, Dawn et al. (2018) The Self-Report Habit Index: Assessing habitual marijuana, alcohol, e-cigarette, and cigarette use. Drug Alcohol Depend 186:207-214
Mota, Natalie P; Han, Shizhong; Harpaz-Rotem, Ilan et al. (2018) Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Depress Anxiety 35:168-177
Leeman, Robert F; Nogueira, Christine; Wiers, Reinout W et al. (2018) A Test of Multisession Automatic Action Tendency Retraining to Reduce Alcohol Consumption Among Young Adults in the Context of a Human Laboratory Paradigm. Alcohol Clin Exp Res 42:803-814
Morean, Meghan E; L'Insalata, Alexa; Butler, Ellyn R et al. (2018) Age at drinking onset, age at first intoxication, and delay to first intoxication: Assessing the concurrent validity of measures of drinking initiation with alcohol use and related problems. Addict Behav 79:195-200
Preller, Katrin H; Burt, Joshua B; Ji, Jie Lisa et al. (2018) Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. Elife 7:
Zhang, Huiping; Zhou, Hang; Lencz, Todd et al. (2018) Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test. Am J Med Genet B Neuropsychiatr Genet 177:511-519
Vijay, Aishwarya; Cavallo, Dana; Goldberg, Alissa et al. (2018) PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age. Neuropsychopharmacology 43:2539-2547
Polimanti, Renato; Kayser, Manfred H; Gelernter, Joel (2018) Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits. Genome Med 10:24
Polimanti, R; Kaufman, J; Zhao, H et al. (2018) A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus. Mol Psychiatry 23:154-160
Polimanti, R; Kaufman, J; Zhao, H et al. (2018) Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers. Acta Psychiatr Scand 137:148-156

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