A gap remains in the translation of basic research advances into clinical neuroscience insights related to alcoholism.. This gap persists despite a growing array of outstanding basic and clinical studies in the field of alcoholism research. A new generation of psychopharmacology, neuroimaging, and molecular genetic studies rooted in molecular neuroscience with broad clinical implications may contribute to bridging the gap between basic and clinical research. The CTNA is designed to bridge the gap between the basic and clinical neuroscience of alcoholism. It will attempt to: 1. Conduct programmatic research that will identify factors modulating glutamatergic circuitry that contribute to ethanol reward, vulnerability to self-administration, and dependence; 2. Build from basic neuroscience insights to hypotheses regarding the etiology, pathophysiology, and treatment of alcoholism; 3. Facilitate transdisciplinary research within projects and between projects; 4. Establish a mechanism to review and fund pilot promising pilot projects; 5. Provide career development activities for graduate and medical students, postdoctoral trainees, and junior faculty that will promote their development and retention within the field of alcoholism research; 6. Promote ethnical and humane clinical neuroscience studies of alcoholism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA012870-05
Application #
6898926
Study Section
Special Emphasis Panel (ZAA1-DD (01))
Program Officer
Witt, Ellen
Project Start
2001-06-04
Project End
2006-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
5
Fiscal Year
2005
Total Cost
$1,800,000
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Vijay, Aishwarya; Cavallo, Dana; Goldberg, Alissa et al. (2018) PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age. Neuropsychopharmacology 43:2539-2547
Polimanti, Renato; Kayser, Manfred H; Gelernter, Joel (2018) Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits. Genome Med 10:24
Polimanti, R; Kaufman, J; Zhao, H et al. (2018) A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus. Mol Psychiatry 23:154-160
Polimanti, R; Kaufman, J; Zhao, H et al. (2018) Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers. Acta Psychiatr Scand 137:148-156
Ide, Jaime S; Zhornitsky, Simon; Chao, Herta H et al. (2018) Thalamic Cortical Error-Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use. Biol Psychiatry Cogn Neurosci Neuroimaging 3:868-877
D'Souza, Deepak Cyril; Carson, Richard E; Driesen, Naomi et al. (2018) Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects. Biol Psychiatry 84:413-421
Polimanti, Renato; Gelernter, Joel; Stein, Dan J (2018) Genetically determined schizophrenia is not associated with impaired glucose homeostasis. Schizophr Res 195:286-289
Foster, Dawn W; Ye, Feifei; O'Malley, Stephanie S et al. (2018) Longitudinal Associations Between Alcohol-Related Cognitions and Use in African American and European American Adolescent Girls. Alcohol Clin Exp Res 42:962-971
Polimanti, Renato; Gelernter, Joel (2018) ADH1B: From alcoholism, natural selection, and cancer to the human phenome. Am J Med Genet B Neuropsychiatr Genet 177:113-125
Zhou, Hang; Cheng, Zhongshan; Bass, Nicholas et al. (2018) Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Transl Psychiatry 8:208

Showing the most recent 10 out of 273 publications