Abstract

Social behavior is affected by prenatal exposure to ethanol. The oxytocin system in the amygdala is thought to play a major role in social behavior. We will test the hypothesis that acute exposure during gastrulation (gestational day (G) 7) or during the time of generation of amygdala neurons (G14) will result in a significant deficit in social behavior. Animals will be given ethanol on G7 or G14. Offspring will undergo social behavior testing then the brains will be collected for analysis of the effect of ethanol on the amygdala. These studies will provide valuable data on the etiology of the social behavior deficits associated with prenatal exposure to ethanol and will begin to examine the mechanism(s) underlying such deficits.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA017823-04
Application #
8381966
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$22,130
Indirect Cost
$4,597

  Institution

Name
State University of NY, Binghamton
Department
Type
DUNS #
090189965
City
Binghamton
State
NY
Country
United States
Zip Code
13902

  Publications

Popoola, Daniel O; Cameron, Nicole M (2018) Maternal care-related differences in males and females rats' sensitivity to ethanol and the associations between the GABAergic system and steroids in males. Dev Psychobiol 60:380-394
Russell, Ashley L; Tasker, Jeffrey G; Lucion, Aldo B et al. (2018) Factors promoting vulnerability to dysregulated stress reactivity and stress-related disease. J Neuroendocrinol 30:e12641
Mooney, Sandra M; Varlinskaya, Elena I (2018) Enhanced sensitivity to socially facilitating and anxiolytic effects of ethanol in adolescent Sprague Dawley rats following acute prenatal ethanol exposure. Alcohol 69:25-32
Lovelock, Dennis F; Deak, Terrence (2018) Neuroendocrine and neuroimmune adaptation to Chronic Escalating Distress (CED): A novel model of chronic stress. Neurobiol Stress 9:74-83
Barney, Thaddeus M; Vore, Andrew S; Gano, Anny et al. (2018) Assessment of Interleukin-6 Signaling Effects on Behavioral Changes Associated with Acute Alcohol Intoxication in adult male rats. Alcohol :
Surkin, P N; Brenhouse, H; Deak, T et al. (2018) Stress, alcohol and infection during early development: A brief review of common outcomes and mechanisms. J Neuroendocrinol 30:e12602
Doremus-Fitzwater, Tamara L; Paniccia, Jacqueline E; Gano, Anny et al. (2018) Differential effects of acute versus chronic stress on ethanol sensitivity: Evidence for interactions on both behavioral and neuroimmune outcomes. Brain Behav Immun 70:141-156
Diaz, Marvin Rafael; Przybysz, Kathryn Renee; Rouzer, Siara K (2018) Age as a factor in stress and alcohol interactions: A critical role for the kappa opioid system. Alcohol 72:9-18
Perkins, Amy E; Vore, Andrew S; Lovelock, Dennis et al. (2018) Late aging alters behavioral sensitivity to ethanol in a sex-specific manner in Fischer 344 rats. Pharmacol Biochem Behav 175:1-9
Akinmboni, T O; Davis, N L; Falck, A J et al. (2018) Excipient exposure in very low birth weight preterm neonates. J Perinatol 38:169-174

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