Alcohol use disorders (AUDs) represent a major public health burden. Genetic risk factors contribute critically to susceptibility to AUDs likely a result of many variants each contributing modestly to risk. Genetic studies in animal models and humans have to date made slow progress in identifying genes individual risk variants. However, modern high-throughput approaches such as genome-wide association studies or genomic expression profiling promise to rapidly increase the pool of potential candidate genes influencing AUDs. This proposal for a P50 Alcohol Research Center presents a novel and highly integrated overall design to focus on both gene discovery and functional interpretation for the genetics of AUDs. This application is the outgrowth of a P20 Developmental Center grant that established the VCU Alcohol Research Center in 2009. Having made significant progress, we propose here to extend and enlarge that Center. Our approach includes three novel features: 1) A focus on gene networks contributing to AUD-related phenotypes, rather than single genes;2) A cross-species genetic and genomics analysis to validate candidate genes and networks affecting ethanol behaviors;3) A highly integrative Center design with rapid data sharing across projects through a cross-species analysis pipeline to provide ranked gene lists or networks for further experimental validation in the component projects. We request five years of support for six research projects and pilot grants for genetic studies in mice, worms, flies, and humans. Three projects will be in human genetics with a novel clinical laboratory component for assessing targeted genetic influences on human behavioral responses to ethanol in a controlled environment. All projects will be supported by an Administrative Core, an Analytic and Informatics Core and a Rodent Behavioral Core. The scientific work proposed in these projects and cores are clearly greater than the sum of their parts, due to the highly interactive structure of the VCU-ARC components. The VCU-ARC is well positioned to become a national resource making major contributions to the advancement of our understanding of the etiology of AUDs and their prevention and treatment.

Public Health Relevance

Use of genetic and genomic data across species can define gene networks mediating ethanol responses and inform candidate gene selection for development of future diagnostic or therapeutic approaches. This focus provides the VCU-ARC a novel and highly significant justification with potential for contributing broadly to the alcohol research field and to public health.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Specialized Center (P50)
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Application #
Study Section
Special Emphasis Panel (ZAA1-GG (50))
Program Officer
Reilly, Matthew
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Virginia Commonwealth University
Schools of Medicine
United States
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Edwards, Alexis C; Deak, Joseph D; Gizer, Ian R et al. (2018) Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity. Alcohol Clin Exp Res 42:2349-2359
Thomas, Nathaniel S; Adkins, Amy; Aliev, Fazil et al. (2018) Alcohol Metabolizing Polygenic Risk for Alcohol Consumption in European American College Students. J Stud Alcohol Drugs 79:627-634
Shell, Brandon C; Schmitt, Rebecca E; Lee, Kristen M et al. (2018) Measurement of solid food intake in Drosophila via consumption-excretion of a dye tracer. Sci Rep 8:11536
Hawn, Sage E; Lind, Mackenzie J; Conley, Abigail et al. (2018) Effects of social support on the association between precollege sexual assault and college-onset victimization. J Am Coll Health 66:467-475
Wolstenholme, Jennifer T; Bowers, M Scott; Pais, Alexander B et al. (2018) Dietary Omega-3 Fatty Acids Differentially Impact Acute Ethanol-Responsive Behaviors and Ethanol Consumption in DBA/2J Versus C57BL/6J Mice. Alcohol Clin Exp Res :
Hawn, Sage E; Sheerin, Christina M; Webb, Bradley T et al. (2018) Replication of the Interaction of PRKG1 and Trauma Exposure on Alcohol Misuse in an Independent African American Sample. J Trauma Stress 31:927-932
Dick, Danielle M; Barr, Peter B; Cho, Seung Bin et al. (2018) Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the ""Other"" Next Steps. Genes Brain Behav 17:e12447
Clark, Shaunna L; Costin, Blair N; Chan, Robin F et al. (2018) A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies. Alcohol Clin Exp Res 42:2360-2368
Tubbs, Justin D; Savage, Jeanne E; Adkins, Amy E et al. (2018) Mindfulness moderates the relation between trauma and anxiety symptoms in college students. J Am Coll Health :1-11
Do, Elizabeth K; Prom-Wormley, Elizabeth C; Fuemmeler, Bernard F et al. (2018) Associations Between Initial Subjective Experiences with Tobacco and Self-Reported Recent Use in Young Adulthood. Subst Use Misuse 53:2291-2298

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