Psychosis is a common behavioral complication of dementia in the elderly, and of Alzheimer's disease (AD) in particular. Although certain limbic structures have been implicated in the cognitive and emotional abnormalities of chronic idiopathic psychosis, little is known about the neuropathological and neuroradiological correlates of psychoses of later onset, including those associated with neurodegenerative disorders. MRI provides the anatomical resolution necessary for in vivo detection of structural abnormalities and has the advantage over neuropathologic data in that results may be correlated with concurrent clinical assessments.
The aim of the present study is to use computer-analyzed MR to estimate volumes of specific cerebral structures in AD patients with and without psychosis in an attempt to identify a possible anatomical substrate of late-onset psychosis. Analysis is proposed on four groups of patients (AD with psychosis, AD without psychosis, Lewy body variant, controls). It is our hypothesis that AD subjects with psychosis will demonstrate similar structural abnormalities with regard to their psychosis, especially involving lenticular, frontal and mesial temporal lobe structures. In the Lewy body variant of AD, where extrapyramidal features are characteristic of the clinical presentation, involvement of basal ganglia structures would be expected to be significantly more prominent. If patients die and have autopsies during the time-frame of the study, neuropathological findings will be correlated with quantitative MR analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005131-13
Application #
5204437
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Saberi, Shahram; Stauffer, Jennifer E; Jiang, Jie et al. (2018) Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathol 135:459-474
Lee, Ming-Hsiang; Siddoway, Benjamin; Kaeser, Gwendolyn E et al. (2018) Somatic APP gene recombination in Alzheimer's disease and normal neurons. Nature 563:639-645
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600

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