This proposal is for a five-year renewal of the Alzheimer's Disease Research Center (ADRC) at the University of California at San Diego in consortium with the Salk Institute. The major objective of our ADRC is to understand the pathogenesis and pathophysiology of AD with the ultimate goal of understanding the etiology sufficiently to be able to prevent it or slow its course. This center is focused on structure- functional relationships, made possibly by the close links between the Clinical and Neuropathology Cores. We will carry out a series of specific clinical pathological correlations complemented by studies of molecular events in AD in order to understand the disease. The ADRC provides an invaluable clinical and neuropathological resource to both ADRC and other AD investigators and to the San Diego community as a whole by making available a well characterized clinical cohort of both Caucasian and Hispanic volunteers who undergo annual evaluations and are willing to participate in clinical research. We also supply brain tissue, fibroblasts, serum, DNA and cerebrospinal fluid to numerous investigators. The Clinical Core also recruits special subjects and controls to support the special needs of many of the individual projects. These cohorts are subjects also participate in both multicenter drug trials and registries such as CERAD. The ADRC provides a setting to facilitate research training of AD investigators and information is transferred to the professional and lay communities through our mini- residency program, conferences and other educational activities. We foster interdisciplinary research activities through collaborations, seminars, feasibility and pilot projects. Our specific research projects in this renewal include research into: The Role of Glutamate Receptor Activation in AD; Beta Amyloid Protein Metabolism in vitro; A novel Amyloid Component; Synaptic Alterations in Rodent Models of AD; Early Brain Structural Changes in Subjects at Risk for proposed including: Human Fetal Neuronal Cultures for AD; Bilingualism and Dementia; Quantitative MRI Analysis of Psychosis in AD; the Deterioration of Semantic Networks in Patients with AD; and the Biological Activity of the Secreted Form of APP-751.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-MJF-2 (02))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Saberi, Shahram; Stauffer, Jennifer E; Jiang, Jie et al. (2018) Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathol 135:459-474
Lee, Ming-Hsiang; Siddoway, Benjamin; Kaeser, Gwendolyn E et al. (2018) Somatic APP gene recombination in Alzheimer's disease and normal neurons. Nature 563:639-645
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600

Showing the most recent 10 out of 914 publications