The University of Pittsburgh ADRC is a multi-disciplinary resource which oversees clinical assessment and care, stimulates dementia research, and trains health professionals in Alzheimer's disease (AD) and other dementias. Centered in the Department of Psychiatry of Western Psychiatry Institute and Clinic, it involves clinicians and investigators from 18 departments in 8 schools at the University. In this competing continuation the ADRC will continue to address its 4 specific aims: to advance research in AD and other dementias, to training physicians and other professionals and to promote understanding of AD and other dementias in the region and nationally. There are 6 cores in the ADRC: the Administrative Core oversees all ADRC functions, and provides scientific initiatives and direction. The Data Management and Analysis Component maintains the ADRC database and provides biostatistical consultation. The Clinical Core performs clinical and research evaluations of patients and controls; follows this cohort longitudinally; and provides clinical data, subjects, and technical and scientific leadership for research for research. It also performs outreach to the African American community via a successful satellite leadership for research. It also performs outreach to the African American community via a successful satellite clinic. The Neuropathology Core provides neuropathologic analyses of all cases, a well catalogued brain bank, and sophisticated image analysis and technical expertise for ADRC investigators. The Training and Information Core provides training in geriatrics and AD, provides outreach to minority groups and rural areas, and systematically evaluates ADRC programs. The Neuroimaging Core provides centralized acquisition, analysis, reporting and archiving of all MR imaging of all MR imaging on ADRC patients, coordinates MR with PET research studies, and provides expertise consultation in design of imaging studies in dementia. The newest core, the Genetics Core, will collect blood and DNA from participants, perform APOE genotyping, and provide genetic material for research collaborations. The projects proposed reflect the broad scientific strengths and resources at the University of Pittsburgh, our ability to attract outstanding researchers to the field, and important domains of inquiry in AD research, with emphasis on genetics, neuroimaging and neuropsychiatry. Project 1 examines functional MRI in semantic memory in AD. Project 2 assesses AChE imaging on PET, in AD patients treated with cholinergic drugs. project 3 studies the role of bleomycin hydrolase, a cysteine protease, on amyloid metabolism and alpha secretase activity. Project 4 will perform the first incidence study of psychosis in AD, and determine the risk of certain neurotransmitter receptor polymorphisms in predisposing to development of psychosis. This proposal illustrates the continuing development of this mature ADRC, and its ability to manage and stimulate productive clinical and basic research, service and training activities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005133-20
Application #
6629737
Study Section
Special Emphasis Panel (ZAG1-PKN-7 (J1))
Program Officer
Phelps, Creighton H
Project Start
1985-09-30
Project End
2005-03-31
Budget Start
2003-05-01
Budget End
2004-03-31
Support Year
20
Fiscal Year
2003
Total Cost
$1,819,642
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Tudorascu, Dana L; Minhas, Davneet S; Lao, Patrick J et al. (2018) The use of Centiloids for applying [11C]PiB classification cutoffs across region-of-interest delineation methods. Alzheimers Dement (Amst) 10:332-339
Lancour, Daniel; Naj, Adam; Mayeux, Richard et al. (2018) One for all and all for One: Improving replication of genetic studies through network diffusion. PLoS Genet 14:e1007306
DeKosky, Steven T; Jaffee, Michael; Bauer, Russell (2018) Long-term Mortality in NFL Professional Football Players: No Significant Increase, but Questions Remain. JAMA 319:773-775
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Snitz, Beth E; Wang, Tianxiu; Cloonan, Yona Keich et al. (2018) Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting. Alzheimers Dement 14:734-742
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Fowler, Nicole R; Shaaban, C Elizabeth; Torke, Alexia M et al. (2018) ""I'm Not Sure We Had A Choice"": Decision Quality and The Use of Cardiac Implantable Electronic Devices In Older Adults With Cognitive Impairment. Cardiol Cardiovasc Med 2:10-26
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27

Showing the most recent 10 out of 667 publications