The Education and Information Transfer Core of the ADRC builds upon nearly 20 years of experience linking education and community outreach efforts to important laboratory-based investigation, as well as the extensive, well-developed educational resources of the Harvard Medical School (HMS) Division on Aging, the Beth Israel Deaconess Medical Center (BIDMC) Gerontology Division, and the Hebrew Rehabilitation Center for Aged (HRCA) Research and Training Institute. The Principal Investigator, Lewis A. Lipsitz, M.D., holds appointments at all 3 institutions, each of which is largely focused on clinical issues related to the care of AD patients. Over the past 5 years we have trained 30 geriatric medicine fellows, 45 medical residents, 19 medical students, 4 post-doctoral research fellows, and 5 postdoctoral nurses in the area of AD and related dementias. We have disseminated information about dementia to over 35,000 community-dwelling elders through presentations, newsletters, and seminars. We have also completed postmortem analyses of 13 normal brains from people whose average age is 90 +/- 7 years. In this application we propose new projects in areas of professional education and information dissemination about AD to the African-American, Chinese-speaking, and Latino populations of Boston. Furthermore, we will continue the successful Memory and Aging Project that collects brains for postmortem examination from cognitively normal elderly individuals.
The specific aims of the Core are: 1) To enhance the professional education of physicians in the diagnosis, management, and investigation of AD, 2) To increase the level of knowledge of non-professional caregivers and all consumers about the manifestations and management of AD and other dementias, and 3) To provide normal brain tissue from well-characterized elderly residents of the Hebrew Rehabilitation Center for Aged who agree to make brain donations to the ADRC Brain Bank when they die. In order to accomplish these goals, the ADRC has allied itself closely with several organizations, including The Massachusetts Alzheimer's Association, Boston Multicultural Coalition on Aging, local hospitals, and the Harvard Division on Aging.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
2P50AG005134-21
Application #
6819668
Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (J4))
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
21
Fiscal Year
2004
Total Cost
$229,615
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Bennett, Rachel E; Robbins, Ashley B; Hu, Miwei et al. (2018) Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease. Proc Natl Acad Sci U S A 115:E1289-E1298
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Lee, Catherine; Betensky, Rebecca A; Alzheimer's Disease Neuroimaging Initiative (2018) Time-to-event data with time-varying biomarkers measured only at study entry, with applications to Alzheimer's disease. Stat Med 37:914-932
Wachinger, Christian; Reuter, Martin; Klein, Tassilo (2018) DeepNAT: Deep convolutional neural network for segmenting neuroanatomy. Neuroimage 170:434-445
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Matsouaka, Roland A; Singhal, Aneesh B; Betensky, Rebecca A (2018) An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome. Stat Methods Med Res 27:2384-2400
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:

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