Abstract

The Massachusetts ADRC established and maintains one of the oldest and most comprehensive clinical databases on AD and related dementias in the country. Its Data Management and Statistics Core was created to support the Center's mission of conducting innovative research on AD and related neurodegenerative disorders, and to sustain collaborative research efforts with other ADCs and national AD research initiatives. Its key personnel work cohesively to: Maintain the ADRC Patient Registry and Neuropathology Brain Registry to serve local ADRC and National Alzheimer's Coordinating Center (NACC) needs; Ensure a seamless transmission of clinical, laboratory and neuropathology data collected during Memory Disorders Unit (MDU) visits and autopsies to the ADRC database; Conduct accurate data entry monitored by computerized range checks and double-checking procedures; Guarantee data confidentiality in accordance with HIPAA (Health Insurance Portability and Accountability Act of 1996) and general patient privacy guidelines; Provide requested data to authorized investigators, both within the ADRC and (inter)nationally, in support of their research endeavors; Submit timely and accurate clinical and neuropathology data to the NACC; Deliver top-quality statistical consultation and execution to ADRC investigators in the various cores and affiliated research projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005134-23
Application #
7210667
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
23
Fiscal Year
2006
Total Cost
$113,490
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529
Quiroz, Yakeel T; Sperling, Reisa A; Norton, Daniel J et al. (2018) Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA Neurol 75:548-556
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Dujardin, Simon; Bégard, Séverine; Caillierez, Raphaëlle et al. (2018) Different tau species lead to heterogeneous tau pathology propagation and misfolding. Acta Neuropathol Commun 6:132
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
DeVos, Sarah L; Corjuc, Bianca T; Commins, Caitlin et al. (2018) Tau reduction in the presence of amyloid-? prevents tau pathology and neuronal death in vivo. Brain 141:2194-2212
Lee, Christopher M; Jacobs, Heidi I L; Marquié, Marta et al. (2018) 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. J Alzheimers Dis 62:1691-1702
Eftekharzadeh, Bahareh; Daigle, J Gavin; Kapinos, Larisa E et al. (2018) Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron 99:925-940.e7

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