Abstract

The main aim of this Core will continue to be the provision of neuropathologic diagnostic expertise to the clinical core, the Satellite Clinic, Projects 1, 2, 3, 4 and 5. We will accomplish this by examination of brains from subjects in these studies, by providing well characterized tissue specimens, and by examining tissue from animal studies.
Other aims i nclude: 1) the rapid removal and freeze-preservation of brain tissue slices from study patients, both normal and demented subjects and make these tissue samples available to interested investigators; 2) quantification of Alzheimer changes in study subjects and controls by automated image analysis; 3) correlate the extent of ApoE deposition in tangles and plaques in old and young AD patients; and 4) correlate the severity of AD changes with the ApoE phenotype of the subjects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005136-13
Application #
5204467
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Goins, R Turner; Schure, Mark; Jensen, Paul N et al. (2018) Lower body functioning and correlates among older American Indians: The Cerebrovascular Disease and Its Consequences in American Indians Study. BMC Geriatr 18:6
Iverson, Grant L; Keene, C Dirk; Perry, George et al. (2018) The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features. J Alzheimers Dis 61:17-28
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Flanagan, Margaret E; Keene, Christopher Dirk; Louis, David N et al. (2018) Localized crystal-storing histiocytosis of the posterior fossa. Neuropathology 38:529-534
Rane, Swati; Koh, Natalie; Boord, Peter et al. (2018) Quantitative cerebrovascular pathology in a community-based cohort of older adults. Neurobiol Aging 65:77-85
Dams-O'Connor, Kristen; Sy, Karla Therese L; Landau, Alexandra et al. (2018) The Feasibility of Telephone-Administered Cognitive Testing in Individuals 1 and 2 Years after Inpatient Rehabilitation for Traumatic Brain Injury. J Neurotrauma 35:1138-1145
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71

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