Abstract

The main aim of this Core will continue to be the provision of neuropathologic diagnostic expertise to the clinical core, the Satellite Clinic, Projects 1, 2, 3, 4 and 5. We will accomplish this by examination of brains from subjects in these studies, by providing well characterized tissue specimens, and by examining tissue from animal studies.
Other aims i nclude: 1) the rapid removal and freeze-preservation of brain tissue slices from study patients, both normal and demented subjects and make these tissue samples available to interested investigators; 2) quantification of Alzheimer changes in study subjects and controls by automated image analysis; 3) correlate the extent of ApoE deposition in tangles and plaques in old and young AD patients; and 4) correlate the severity of AD changes with the ApoE phenotype of the subjects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005136-13
Application #
5204467
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Keene, C Dirk; Wilson, Angela M; Kilgore, Mitchell D et al. (2018) Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Lab Invest :
Locke, Timothy M; Soden, Marta E; Miller, Samara M et al. (2018) Dopamine D1 Receptor-Positive Neurons in the Lateral Nucleus of the Cerebellum Contribute to Cognitive Behavior. Biol Psychiatry 84:401-412
Edlow, Brian L; Keene, C Dirk; Perl, Daniel P et al. (2018) Multimodal Characterization of the Late Effects of Traumatic Brain Injury: A Methodological Overview of the Late Effects of Traumatic Brain Injury Project. J Neurotrauma 35:1604-1619
Flanagan, Margaret E; Cholerton, Brenna; Latimer, Caitlin S et al. (2018) TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study. J Alzheimers Dis 66:1549-1558
Akhter, Rumana; Shao, Yvonne; Shaw, McKenzie et al. (2018) Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer's disease. Neurobiol Aging 63:110-119
Mukherjee, Shubhabrata; Mez, Jesse; Trittschuh, Emily H et al. (2018) Genetic data and cognitively defined late-onset Alzheimer's disease subgroups. Mol Psychiatry :
Turk, Katherine W; Flanagan, Margaret E; Josephson, Samuel et al. (2018) Psychosis in Spinocerebellar Ataxias: a Case Series and Study of Tyrosine Hydroxylase in Substantia Nigra. Cerebellum 17:143-151

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