Despite remarkable advances in clinical and basic research on Alzheimer's disease over the past decade, ethnic minority groups have remained under- represented both in research populations and as beneficiaries of new findings. The University of Washington's ADRC Satellite Core aims to help reduce this racial and economic disparity through several interdigitating programs. The Satellite has developed cohorts of well-characterized elderly ethnic minority subjects, both with and without AD, who are followed longitudinally. Through collaborative efforts with ethnic minority service agencies throughout Washington state, it contributes to the training of community health and social service providers in effective management of the many clinical problems associated with progression of AD and related dementias. Through its focus on ethnic minorities, the Satellite makes new populations available for research on genetic determinants of dementing disorders, the contribution of education and medical comorbidities to development and course of dementia, and special caregiver needs. Through its linkage with the clinical geriatric training programs in medicine and psychiatry at the University of Washington, it sensitizes physicians to minority issues in the care of demented patients and provides a base for developing new research initiatives. Over the next five years, the Satellite will further expand representation of Washington's multi-ethnic communities in AD research through enhancement of existing community collaborations, active outreach to create new community linkages, and specific targeting strategies appropriate to African-Americans, Native Americans, Asian-Americans, and Hispanic elderly. As a Core of the ADRC, the Satellite will continue to provide subjects as appropriate to the needs of other AD investigators at the University of Washington. Nationally, it is committed to building synergy among ADRC Satellites to enhance research on minority elders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG005136-16S1
Application #
6216967
Study Section
Project Start
1999-08-15
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Tulloch, Jessica; Leong, Lesley; Chen, Sunny et al. (2018) APOE DNA methylation is altered in Lewy body dementia. Alzheimers Dement 14:889-894
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Kunji, Khalid; Ullah, Ehsan; Nato Jr, Alejandro Q et al. (2018) GIGI-Quick: a fast approach to impute missing genotypes in genome-wide association family data. Bioinformatics 34:1591-1593
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124
Taylor, Laura M; McMillan, Pamela J; Liachko, Nicole F et al. (2018) Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration. Mol Neurodegener 13:7
Flanagan, Margaret E; Larson, Eric B; Walker, Rod L et al. (2018) Associations between Use of Specific Analgesics and Concentrations of Amyloid-? 42 or Phospho-Tau in Regions of Human Cerebral Cortex. J Alzheimers Dis 61:653-662
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Tulloch, Jessica; Leong, Lesley; Thomson, Zachary et al. (2018) Glia-specific APOE epigenetic changes in the Alzheimer's disease brain. Brain Res 1698:179-186

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