application): Ethnic minorities are the fastest-growing segment of the older population of the United States but remain under-represented in clinical research on Alzheimer's disease and other neurodegenerative dementias, particularly in areas related to health services. The University of Washington Satellite is a clinical core of the ADRC specialized for the recruitment of ethnic minorities for research, developmental studies of recruitment, assessment, and intervention methodologies, and training of young investigators for research on dementia in minority populations. A rich database on over 450 multi-ethnic, multi-lingual community elders has been developed and will continue to form the basis for publications in the renewal period. New work proposed for this renewal will focus on and accelerate recruitment in Asian and African-American elderly, the two largest ethnic minority groups in the Pacific Northwest, using community-based screening to supplement ongoing productive collaborations with social services agencies, to achieve a minimum target sample of 250 new enrollees in the satellite core during the next five years. Initial aims are to validate a simple dementia screening instrument apparently free of language and education biases in a population-based sample of ethnic elderly, enrich the knowledge base on health care and social services needs of demented ethnic elders and their families, develop qualitative research methods grounded in the literature on Chinese and African-Americans to design effective recruitment and intervention strategies, and promote academic career development for three junior investigators in research on cognitive aging and dementia.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG005136-19S2
Application #
6658245
Study Section
Project Start
2002-09-15
Project End
2003-04-30
Budget Start
Budget End
Support Year
19
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Flanagan, Margaret E; Cholerton, Brenna; Latimer, Caitlin S et al. (2018) TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study. J Alzheimers Dis 66:1549-1558
Edlow, Brian L; Keene, C Dirk; Perl, Daniel P et al. (2018) Multimodal Characterization of the Late Effects of Traumatic Brain Injury: A Methodological Overview of the Late Effects of Traumatic Brain Injury Project. J Neurotrauma 35:1604-1619
Mukherjee, Shubhabrata; Mez, Jesse; Trittschuh, Emily H et al. (2018) Genetic data and cognitively defined late-onset Alzheimer's disease subgroups. Mol Psychiatry :
Akhter, Rumana; Shao, Yvonne; Shaw, McKenzie et al. (2018) Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer's disease. Neurobiol Aging 63:110-119
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Turk, Katherine W; Flanagan, Margaret E; Josephson, Samuel et al. (2018) Psychosis in Spinocerebellar Ataxias: a Case Series and Study of Tyrosine Hydroxylase in Substantia Nigra. Cerebellum 17:143-151
Bharadwaj, Rajnish; Cimino, Patrick J; Flanagan, Margaret E et al. (2018) Application of the condensed protocol for the NIA-AA guidelines for the neuropathological assessment of Alzheimer's disease in an academic clinical practice. Histopathology 72:433-440
Petyuk, Vladislav A; Chang, Rui; Ramirez-Restrepo, Manuel et al. (2018) The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target. Brain 141:2721-2739
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325

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