Research on the causes, course, and detection of cognitive impairment in ethnic minorities has begun to bear fruit, particularly over the last ten years. However, in the United States, studies of cognition in African American and Hispanic elderly have far outpaced those in Asian Americans, the largest minority group in the Pacific Northwest, and rates of participation of minorities in mainstream research on dementia continue to be relatively low. The University of Washington ADRC Satellite seeks to identify and enroll older Asian Americans in a NACC-compliant registry for research, emphasizing early stage cognitive decline, encouraging participation in ongoing research projects, and, in keeping with the Center's strong focus on genetic factors in dementia, identifying and locating familial cases for studies of genetic differences. We have the unique opportunity to resume studies of nearly 2000 older Japanese Americans enrolled in the NIA-funded Kame project over 10 years ago. The first 18 months of the proposed project will be dedicated to developing essential infrastructure for these aims, convening a new Community Advisory Board, creating a computerized family history database from raw research records, and identifying subjects who may be appropriate for dementia-related studies. We will emphasize (1) US-born Japanese with a positive family history of dementia, especially those with 'loaded'families;(2) Individuals with and without dementia who are willing to be contacted as potential subjects in research on cognitive impairment;and (3) Individuals who had begun to show early signs of cognitive decline from normal during their last Kame assessment. During the remainder of the funding period, up to 200 Japanese American subjects will be individually re-evaluated using both the Cognitive Abilities Screening Instrument, for continuity with earlier Kame data and Satellite projects, and the NACC Uniform Data Set.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005136-26
Application #
7813852
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
26
Fiscal Year
2009
Total Cost
$237,138
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Moreno, Monica A; Or-Geva, Noga; Aftab, Blake T et al. (2018) Molecular signature of Epstein-Barr virus infection in MS brain lesions. Neurol Neuroimmunol Neuroinflamm 5:e466
Wang, Lucy Y; Raskind, Murray A; Wilkinson, Charles W et al. (2018) Associations between CSF cortisol and CSF norepinephrine in cognitively normal controls and patients with amnestic MCI and AD dementia. Int J Geriatr Psychiatry 33:763-768
Condello, Carlo; Lemmin, Thomas; Stöhr, Jan et al. (2018) Structural heterogeneity and intersubject variability of A? in familial and sporadic Alzheimer's disease. Proc Natl Acad Sci U S A 115:E782-E791
Blue, E E; Yu, C-E; Thornton, T A et al. (2018) Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease. Genes Brain Behav 17:e12429
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Goins, R Turner; Schure, Mark; Jensen, Paul N et al. (2018) Lower body functioning and correlates among older American Indians: The Cerebrovascular Disease and Its Consequences in American Indians Study. BMC Geriatr 18:6
Iverson, Grant L; Keene, C Dirk; Perry, George et al. (2018) The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features. J Alzheimers Dis 61:17-28
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Flanagan, Margaret E; Keene, Christopher Dirk; Louis, David N et al. (2018) Localized crystal-storing histiocytosis of the posterior fossa. Neuropathology 38:529-534

Showing the most recent 10 out of 753 publications