Abstract

This application constitutes the fourth competitive renewal of the Mount Sinai School of Medicine Alzheimer's Disease Research Center. Its fundamental goals have not change since the first funding period, however it has expanded much since then. In this renewal the following cores and projects are propose: . Clinical Research Support Core/El hurst Satellite (D. Marin) . Information Transfer Core (R. Mohs) . Neuropathology Core (D. Perl) . Project: """"""""Molecular Genetic Studies of Neurofilament Assembly and Function"""""""" (R. Lazzarini) . Project: """"""""Quantitative Indices of Neuron Vulnerability in Dementia"""""""" (P. Hof) . Project: """"""""Novel Presenilin Binding Proteins"""""""" (J. Buxbaum) . Project: """"""""Vascular Localization and Function of Presenilin 1 Fragments (N. Robakis) . Project: """"""""An alpha2 Agonist and Cholinesterase Inhibitor in AD"""""""" . Project: """"""""Risk Factors in Very Late Onset AD"""""""" (J. Silverman)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG005138-16S2
Application #
6132197
Study Section
Special Emphasis Panel (ZAG1 (J5))
Project Start
1984-09-28
Project End
2004-03-31
Budget Start
1999-08-15
Budget End
2000-03-31
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Psychiatry
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Ki?emet-Piska?, Spomenka; Babi? Leko, Mirjana; Blažekovi?, Antonela et al. (2018) Evaluation of cerebrospinal fluid phosphorylated tau231 as a biomarker in the differential diagnosis of Alzheimer's disease and vascular dementia. CNS Neurosci Ther 24:734-740
Soleimani, Laili; Ravona-Springer, Ramit; Heymann, Anthony et al. (2018) Depression is more strongly associated with cognition in elderly women than men with type 2 diabetes. Int Psychogeriatr :1-5
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Audrain, Mickael; Haure-Mirande, Jean-Vianney; Wang, Minghui et al. (2018) Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Mol Psychiatry :
Boban, Mirta; Babi? Leko, Mirjana; Miški?, Terezija et al. (2018) Human neuroblastoma SH-SY5Y cells treated with okadaic acid express phosphorylated high molecular weight tau-immunoreactive protein species. J Neurosci Methods :
Zhu, Carolyn W; Grossman, Hillel; Neugroschl, Judith et al. (2018) A randomized, double-blind, placebo-controlled trial of resveratrol with glucose and malate (RGM) to slow the progression of Alzheimer's disease: A pilot study. Alzheimers Dement (N Y) 4:609-616
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Silverman, Jeremy M; Schmeidler, James (2018) Outcome age-based prediction of successful cognitive aging by total cholesterol. Alzheimers Dement 14:952-960

Showing the most recent 10 out of 555 publications