Abstract

This application constitutes the fourth competitive renewal of the Mount Sinai School of Medicine Alzheimer's Disease Research Center. Its fundamental goals have not change since the first funding period, however it has expanded much since then. In this renewal the following cores and projects are propose: . Clinical Research Support Core/El hurst Satellite (D. Marin) . Information Transfer Core (R. Mohs) . Neuropathology Core (D. Perl) . Project: """"""""Molecular Genetic Studies of Neurofilament Assembly and Function"""""""" (R. Lazzarini) . Project: """"""""Quantitative Indices of Neuron Vulnerability in Dementia"""""""" (P. Hof) . Project: """"""""Novel Presenilin Binding Proteins"""""""" (J. Buxbaum) . Project: """"""""Vascular Localization and Function of Presenilin 1 Fragments (N. Robakis) . Project: """"""""An alpha2 Agonist and Cholinesterase Inhibitor in AD"""""""" . Project: """"""""Risk Factors in Very Late Onset AD"""""""" (J. Silverman)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005138-18
Application #
6371682
Study Section
Special Emphasis Panel (ZAG1-PCR-3 (J5))
Program Officer
Phelps, Creighton H
Project Start
1984-09-28
Project End
2004-03-31
Budget Start
2001-04-15
Budget End
2002-03-31
Support Year
18
Fiscal Year
2001
Total Cost
$2,338,571
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Psychiatry
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Bryois, Julien; Garrett, Melanie E; Song, Lingyun et al. (2018) Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia. Nat Commun 9:3121
Miller, M L; Ren, Y; Szutorisz, H et al. (2018) Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability. Mol Psychiatry 23:1328-1335
Fazio, Leonardo; Pergola, Giulio; Papalino, Marco et al. (2018) Transcriptomic context of DRD1 is associated with prefrontal activity and behavior during working memory. Proc Natl Acad Sci U S A 115:5582-5587
Gusev, Alexander; Mancuso, Nicholas; Won, Hyejung et al. (2018) Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nat Genet 50:538-548
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Khan, Atlas; Liu, Qian; Wang, Kai (2018) iMEGES: integrated mental-disorder GEnome score by deep neural network for prioritizing the susceptibility genes for mental disorders in personal genomes. BMC Bioinformatics 19:501
Wang, Jen-Chyong; Alinaghi, Somayeh; Tafakhori, Abbas et al. (2018) Genetic screening in two Iranian families with early-onset Alzheimer's disease identified a novel PSEN1 mutation. Neurobiol Aging 62:244.e15-244.e17
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325

Showing the most recent 10 out of 555 publications