Abstract

The Alzheimer's Disease Research Center Consortium of Southern California is built on Clinical and Autopsy Cores which characterizes patients tentatively diagnosed as Alzheimer's disease and controls which include healthy elderly and others with various neurological disease. At death, the Autopsy and Cell Quantimetrics Core complete the diagnosis. Tissues of carefully selected Alzheimer's Disease cases and various controls are distributed to Participating Investigators for a wide range of basic and clinical studies on the genetic, biochemical and structural phenomena of Alzheimer's Disease and non-clinical age changes. Longitudinal studies of Alzheimer's Disease patients are evaluating subtypes and Alzheimer's Disease's impact on family and caregivers. Training/Information Transfer exposes research trainees and newly involved Investigators to the biomedical and psychosocial aspects of Alzheimer's Disease, and disseminates needed information to Alzheimer', Disease victims and caregivers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005142-07
Application #
3104804
Study Section
Aging Review Committee (AGE)
Project Start
1984-09-28
Project End
1994-03-31
Budget Start
1990-07-01
Budget End
1991-03-31
Support Year
7
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
Organized Research Units
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Aydogan, Dogu Baran; Jacobs, Russell; Dulawa, Stephanie et al. (2018) When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity. Brain Struct Funct 223:2841-2858
Gahm, Jin Kyu; Shi, Yonggang; Alzheimer’s Disease Neuroimaging Initiative (2018) Riemannian metric optimization on surfaces (RMOS) for intrinsic brain mapping in the Laplace-Beltrami embedding space. Med Image Anal 46:189-201
Emrani, Sheina; Libon, David J; Lamar, Melissa et al. (2018) Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall. J Alzheimers Dis 61:917-928
Hernandez, Gerson; Zhao, Liqin; Franke, Adrian A et al. (2018) Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor ?-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women. Menopause 25:191-196
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360

Showing the most recent 10 out of 590 publications