Abstract

The Alzheimer's Disease Research Center Consortium of Southern California is built on Clinical and Autopsy Cores which characterizes patients tentatively diagnosed as Alzheimer's disease and controls which include healthy elderly and others with various neurological disease. At death, the Autopsy and Cell Quantimetrics Core complete the diagnosis. Tissues of carefully selected Alzheimer's Disease cases and various controls are distributed to Participating Investigators for a wide range of basic and clinical studies on the genetic, biochemical and structural phenomena of Alzheimer's Disease and non-clinical age changes. Longitudinal studies of Alzheimer's Disease patients are evaluating subtypes and Alzheimer's Disease's impact on family and caregivers. Training/Information Transfer exposes research trainees and newly involved Investigators to the biomedical and psychosocial aspects of Alzheimer's Disease, and disseminates needed information to Alzheimer', Disease victims and caregivers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005142-09
Application #
3104806
Study Section
Aging Review Committee (AGE)
Project Start
1984-09-28
Project End
1994-03-31
Budget Start
1992-05-10
Budget End
1993-03-31
Support Year
9
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
Organized Research Units
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Petok, Jessica R; Myers, Catherine E; Pa, Judy et al. (2018) Impairment of memory generalization in preclinical autosomal dominant Alzheimer's disease mutation carriers. Neurobiol Aging 65:149-157
Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin et al. (2018) Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement 14:205-214
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27
Weissberger, Gali H; Nation, Daniel A; Nguyen, Caroline P et al. (2018) Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans. Neurosci Biobehav Rev 94:49-58
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Wang, Junyan; Aydogan, Dogu Baran; Varma, Rohit et al. (2018) Modeling topographic regularity in structural brain connectivity with application to tractogram filtering. Neuroimage 183:87-98

Showing the most recent 10 out of 590 publications