This ADRC consortium represents more than 100 faculty-level Participating Investigators with major interests in Alzheimer disease and the neurobiology of aging. Most studies are performed in facilities for basic and clinical research at the University of Southern California (USC) and the University of California at Irvine (UCI). Basic research emphasizes molecular mechanisms in neurodegeneration. Clinical research emphasizes new diagnostics and interventions for AD victims and their care-givers. Besides the required Cores [Administrative, Clinical, Neuropathology, and Research Training and Information Transfer Cores], we have Cores for Genetic Epidemiology, Pharmacology, and a Satellite at Cal State Los Angels (CSLA). A new Neuro-imaging Core is proposed. Program at CSLA and in other Cores address minorities that are under-represented in research on Alzheimer's disease, in order to increase access of the victims to new diagnoses and treatments, as well as to reduce the burden of care-givers. A common database is being constructed through the Teradata relational database computer at UCI that will be accessible to researchers throughout this ADRC.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005142-14
Application #
2390009
Study Section
Special Emphasis Panel (ZAG1-MJF-2 (01))
Project Start
1984-09-28
Project End
1999-03-31
Budget Start
1997-04-15
Budget End
1998-03-31
Support Year
14
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Southern California
Department
Miscellaneous
Type
Organized Research Units
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Sweeney, Melanie D; Kisler, Kassandra; Montagne, Axel et al. (2018) The role of brain vasculature in neurodegenerative disorders. Nat Neurosci 21:1318-1331
Nation, Daniel A (2018) Blood Pressure and Cerebral Blood Flow in Alzheimer Disease. Hypertension 72:68-69
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Aydogan, Dogu Baran; Jacobs, Russell; Dulawa, Stephanie et al. (2018) When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity. Brain Struct Funct 223:2841-2858

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