Abstract

This renewal of AG-05142 proposes an Alzheimer Disease Research Center (ADRC) program seated at USC with 4 aims and 4 new projects.
Aim 1 : Identify molecular and cellular mechanisms of neurodegeneration during D and normal aging processes.
Aim 2 : Develop hormonal interventions into age-related cognitive changes with clinical studies and animal models.
Aim 3 : Develop cognitive & imaging techniques to monitor aging, AD, & clinical interventions.
Aim 4 : Increase participation of Hispanic, African-American, and other minorities in drug trials. The USC-ADRC is comprised of the required cores and two special-service cores*: Clinical Core: Dir., Victor Henderson; co-Dir. Lon Schneider (Pharmacology Program). Minority Diagnosis and Treatment Satellite*, Dr. Helena Chui. Neuroimaging Core*, Dr. Manbir Singh. Neuropathology Core, Dir. Carol Miller. Education Information Transfer Core, Dir, Bob Knight. These cores serve four new projects of USC faculty: Proj. Alzheimer-like pathology in inclusion-body myopathy (Valerie Askanas). Proj. Choroid plexus in Abeta/apolipoprotein CNS homeostasis (Berislav Zlokovic). Proj. Aberrant DNA synthesis in dividing and non-dividing cells (Myron Goodman). Proj. fMRI studies of working memory, estrogen, & aging (MaryEllen MacDonald and Manbir Singh). The Cores also support a collaborative longitudinal study with Kaiser Permanente: Alzheimer disease & estrogen replacement; Galen Buckwater, co-PI) and two NIA program projects: Models of estrogen interactions with AD and The aging brain: vasculature, ischemia, & behavior. Genotypes of human subjects are obtained through the Molecular Biology Core of the NIEHS enter (John Peters, Dir.) Other users of these resources includes >40 federally funded USC faculty (Schools of Medicine; of Pharmacy; of Gerontology of Letters, Arts, & Sciences; and of Engineering), as well as >20 non-USC researchers. Collaborations with ADRCs of UCLA, UC Irvine, UC San Diego, Boston U, Columbia, Emory, Washington U, U Washington. These approaches to AD build on AD build on USC's long-standing commitment to research and education on aging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005142-18
Application #
6371683
Study Section
Special Emphasis Panel (ZAG1-BJS-3 (J5))
Program Officer
Phelps, Creighton H
Project Start
1984-09-28
Project End
2004-03-31
Budget Start
2001-05-01
Budget End
2002-03-31
Support Year
18
Fiscal Year
2001
Total Cost
$1,661,939
Indirect Cost

  Institution

Name
University of Southern California
Department
Miscellaneous
Type
Organized Research Units
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Wang, Junyan; Aydogan, Dogu Baran; Varma, Rohit et al. (2018) Modeling topographic regularity in structural brain connectivity with application to tractogram filtering. Neuroimage 183:87-98
Joe, Elizabeth; Medina, Luis D; Ringman, John M et al. (2018) 1H MRS spectroscopy in preclinical autosomal dominant Alzheimer disease. Brain Imaging Behav :
Aydogan, Dogu Baran; Shi, Yonggang (2018) Tracking and validation techniques for topographically organized tractography. Neuroimage 181:64-84
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37

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