The Clinical core serves the USC Alzheimer's Disease Research Center and supports regional and national Alzheimer research by developing and maintaining longitudinal cohorts of diverse backgrounds that contribute to research into the prevention and treatment of late-life cognitive impairment and neurodegeneration. The primary role of the ADRC Clinical core is to provide systematic data to the National Alzheimer Coordinating Center (NACC), local and national research studies, and well-characterized, longitudinally- followed participants who range from cognitively non-impaired to dementia. The core is organized to support the USC ADRC's focus on Latinos, its scientific themes vascular factors in Alzheimer disease, and translational research. Hence, the target samples for the core include cognitively non-impaired and impaired with and without vascular risk factors, Latinos, participants who will donate their brains for autopsy, i.e., the brain research study, and participants for clinical translational studies and clinical trials. The Clinical core works with the other ADRC cores to meet its goals to: (1) advance clinical research on Alzheimer-related disorders by supporting ADRC-affiliated research projects including the vascular risk factors and neurodegeneration projects; (2) recruiting, assessing, and following participants in the brain research (autopsy) study in collaboration with the Neuropathology core to enhance the scientific value of autopsies, share data and bio-specimens with researchers, and perform clinicopathological correlation to improve diagnoses; (3) contribute to and advance innovation and the development of methods to better detect, diagnose and intervene in cognitive impairment; and (4) recruit our diverse community's participation in research, lower barriers to access, inform and educate by training students, physicians, and research associates by working with the Outreach, Recruitment, and Education core.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Los Angeles
United States
Zip Code
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Ho, Jean K; Nation, Daniel A; Alzheimer’s Disease Neuroimaging Initiative (2018) Neuropsychological Profiles and Trajectories in Preclinical Alzheimer's Disease. J Int Neuropsychol Soc 24:693-702
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Tang, Yuchun; Sun, Wei; Toga, Arthur W et al. (2018) A probabilistic atlas of human brainstem pathways based on connectome imaging data. Neuroimage 169:227-239
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Babulal, Ganesh M; Quiroz, Yakeel T; Albensi, Benedict C et al. (2018) Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimers Dement :

Showing the most recent 10 out of 590 publications