This Alzheimer's Disease Research Center proposal contains three specific core modules: 1) A Clinical Core which will recruit, evaluate and longitudinally follow and maintain a pool of AD patients for optimal care and clinical investigation and to serve potentially as subjects for autopsy. All will be included in a Dementia Registry and all data will be maintained in a central file. A protocol for quantitative nuclear magnetic resonance scans of AD patients for evaluation of its diagnostic utility is in- cluded. 2) The Tissue Specimen Core provides a coordinated neuropathological/neurochemical assessment facility on autopsy tissues for verification of AD for a variety of correlative clinical-biochemical-morphological research studies. 3) The Training and Information Core will provide research training to health professional students, postdoctoral fellows and faculty and continuing education to practitioners in the communities and state. To complement our AD Program Project Grant which will evaluate potential biochemical and morphological pathogenetic mechanisms in AD, one new RO-1 project is included in this proposal. It will investigate the role of calmodulin, calmodulin binding pro- teins and selected calmodulin regulated enzymes in AD brains, erythrocytes and leukocytes. We have attracted six new investigators from a broad spectrum of disciplines to perform pilot projects in AD. Proposed pilot studies include 1) investigation of the biochemical nature of neurofibrillary tangles, 2) alterations in genes on chromosome 21 in AD brains and lymphocytes, 3) evaluation at a cognitive retraining program for AD patients, 4) study of AD astrocytes' ability to express Ia antigen, produce IL-l and present antigen, 5) studies of coping capacities of AD families over time, 6) morphometric study of synaptic density correlated with senile plaque number in AD brain. All of the foregoing components are tied together by a strong administrative component. This component provides an administrative unit for day-to-day operations and leadership of the ADRC, an Executive Committee, a University-wide Advisory Committee to integrate the ADRC into existing University structures, and an External Advisory Committee to review proposed pilot projects and the ADRC itself. The University of Kentucky has provided significant new resources to support AD related activities at the Sanders-Brown Research Center.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005144-03
Application #
3104816
Study Section
Aging Review Committee (AGE)
Project Start
1985-09-30
Project End
1990-09-29
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Broster, Lucas S; Li, Juan; Wagner, Benjamin et al. (2018) Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex. J Clin Exp Neuropsychol 40:761-776
Petyuk, Vladislav A; Chang, Rui; Ramirez-Restrepo, Manuel et al. (2018) The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target. Brain 141:2721-2739
Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384
Reed, Rebecca G; Greenberg, Richard N; Segerstrom, Suzanne C (2017) Cytomegalovirus serostatus, inflammation, and antibody response to influenza vaccination in older adults: The moderating effect of beta blockade. Brain Behav Immun 61:14-20
Li, Juan; Broster, Lucas S; Jicha, Gregory A et al. (2017) A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging. Alzheimers Res Ther 9:3
Karch, Celeste M; Ezerskiy, Lubov A; Bertelsen, Sarah et al. (2016) Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One 11:e0148717
Mez, Jesse; Mukherjee, Shubhabrata; Thornton, Timothy et al. (2016) The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiol Aging 41:115-121
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-200.e20
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150
Wei, Shaoceng; Kryscio, Richard J (2016) Semi-Markov models for interval censored transient cognitive states with back transitions and a competing risk. Stat Methods Med Res 25:2909-2924

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