Abstract

In order to understand some of the functions of neurons in the basal forebrain in magnocellular complex (BFMC), it is essential to identify the sources and transmitter specificities of afferents to this system. Using axonal tracing and transmitter immunocytochemistry (ICC), Pilot 4 is designed to characterize, at the light and ultrastructural levels, neural systems that innervate BFMC cholinergic neurons in rodents. The anterograde tracer Phaseolus vulagaris leukoagglutinin (PHA-L) will be iontophoresed into regions known to be labeled following injections of retrograde tracer into subdivisions of the BFMC, and dual-color ICC will be employed to identify specific interactions between PHA-L-labeled boutons and cholinergic neurons. Monoaminergic, cholinergic, gamma- aminobutyric acid (GABA)ergic, and peptidergic transmitter-specific interactions with cholinergic neurons of the BFMC will be identified at the electron-microscopic level using double-label ICC> These studies will provide new insights concerning afferents that modulate cholinergic BFMC neurons in rodents and are essential for similar investigations of these afferents in primates.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
2P50AG005146-07
Application #
3813998
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

van Bergen, Jiri M G; Li, Xu; Quevenco, Frances C et al. (2018) Low cortical iron and high entorhinal cortex volume promote cognitive functioning in the oldest-old. Neurobiol Aging 64:68-75
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Kim, Sangjune; Yun, Seung Pil; Lee, Saebom et al. (2018) GBA1 deficiency negatively affects physiological ?-synuclein tetramers and related multimers. Proc Natl Acad Sci U S A 115:798-803
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Hohman, Timothy J; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol 75:989-998
Kageyama, Yusuke; Saito, Atsushi; Pletnikova, Olga et al. (2018) Amyloid ? toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. Sci Rep 8:16895
Kales, Helen C; Gitlin, Laura N; Stanislawski, Barbara et al. (2018) Effect of the WeCareAdvisor™ on family caregiver outcomes in dementia: a pilot randomized controlled trial. BMC Geriatr 18:113
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Reagh, Zachariah M; Noche, Jessica A; Tustison, Nicholas J et al. (2018) Functional Imbalance of Anterolateral Entorhinal Cortex and Hippocampal Dentate/CA3 Underlies Age-Related Object Pattern Separation Deficits. Neuron 97:1187-1198.e4

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