Abstract

Autopsy examination of brain tissue is necessary to determine the accuracy of a diagnosis of Alzheimer's disease (AD) in a longitudinally followed sample of individuals with probable AD. Proxy consent for autopsy is necessary for demented patients, and little is known about the variables that predict consent. To clarify this issue, the designated next-of-kin of ADRC patients (n=50) with probable/possible AD, currently residing in nursing homes, will be interviewed by telephone about their attitudes concerning autopsy. All proxies have given their verbal consent for an autopsy on the patient. Patients will be followed, and, when they die, consent for autopsy will be sought from the next-of-kin. Three months after the patient's death, the proxy will be reinterviewed by telephone about his/her reasons for granting/refusing consent for autopsy. An understanding of the variables that underlie the decisions of proxies to grant/refuse permission for autopsy will allow us to improve our methods of introducing this difficult topic to families and, ultimately, to improve our rate of autopsy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005146-11
Application #
3768111
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Kim, Jeongyong; Bandeen-Roche, Karen (2018) Parametric estimation of association in bivariate failure-time data subject to competing risks: sensitivity to underlying assumptions. Lifetime Data Anal :
Bilgel, Murat; An, Yang; Helphrey, Jessica et al. (2018) Effects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults. Brain :
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Yasar, Sevil; Varma, Vijay R; Harris, Gregory C et al. (2018) Associations of Angiotensin Converting Enzyme-1 and Angiotensin II Blood Levels and Cognitive Function. J Alzheimers Dis 63:655-664
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Pettigrew, Corinne; Shao, Yi; Zhu, Yuxin et al. (2018) Self-reported Lifestyle Activities in Relation to Longitudinal Cognitive Trajectories. Alzheimer Dis Assoc Disord :
Behrens, Stephanie; Rattinger, Gail B; Schwartz, Sarah et al. (2018) Use of FDA approved medications for Alzheimer's disease in mild dementia is associated with reduced informal costs of care. Int Psychogeriatr 30:1499-1507
Habes, Mohamad; Sotiras, Aristeidis; Erus, Guray et al. (2018) White matter lesions: Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy. Neurology 91:e964-e975
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Peng, Shin-Lei; Chen, Xi; Li, Yang et al. (2018) Age-related changes in cerebrovascular reactivity and their relationship to cognition: A four-year longitudinal study. Neuroimage 174:257-262

Showing the most recent 10 out of 830 publications