The Data Management and Statistics Core (Core C) of the Johns Hopkins Alzheimer's Disease Research Center (ADRC) has two overarching goals: (1) to provide database design, data management and data distribution for investigators associated with the ADRC, (2) to provide statistical expertise to investigators associated with the ADRC, including consultation to projects associated with the ADRC, development of novel analytic methods, and mentoring young statisticians. Through the provision of efficient database design and data management, Core C assures the accuracy, accessibility, and integration of data from the ADRC, and provides data sets to the National Alzheimer's Coordinating Center (NACC) and to investigators associated with the ADRC, both within the institution and at other ADC sites. Through the provision of high level statistical consultation to investigators associated with the Center, a range of projects related to the ADRC have been facilitated, novel methods have been developed, and young investigators have been trained in longitudinal methods related to cognitive decline and dementia. In the next funding cycle the Data Management and Statistics Core will continue with these aims.
The Johns Hopkins Alzheimer's Disease Research Center (ADRC) will address many of the topics important to dementia research, with a particular focus on the understanding the earliest phases of Alzheimer's disease (AD). This approach is important if we are ultimately going to be able to diagnose and treat AD as early as possible. The ADRC fosters interactions among scientists who are pursuing this overarching theme.
|Chen, Lin; Wei, Zhiliang; Chan, Kannie W Y et al. (2018) Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI. Neuroimage 188:380-390|
|Ayhan, Fatma; Perez, Barbara A; Shorrock, Hannah K et al. (2018) SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F. EMBO J 37:|
|Sathe, Gajanan; Na, Chan Hyun; Renuse, Santosh et al. (2018) Phosphotyrosine profiling of human cerebrospinal fluid. Clin Proteomics 15:29|
|Martin, Lee J; Chang, Qing (2018) DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different. J Neuropathol Exp Neurol 77:636-655|
|Gomez, Gabriela; Beason-Held, Lori L; Bilgel, Murat et al. (2018) Metabolic Syndrome and Amyloid Accumulation in the Aging Brain. J Alzheimers Dis 65:629-639|
|Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325|
|Kim, Jeongyong; Bandeen-Roche, Karen (2018) Parametric estimation of association in bivariate failure-time data subject to competing risks: sensitivity to underlying assumptions. Lifetime Data Anal :|
|Bilgel, Murat; An, Yang; Helphrey, Jessica et al. (2018) Effects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults. Brain :|
|Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600|
|Yasar, Sevil; Varma, Vijay R; Harris, Gregory C et al. (2018) Associations of Angiotensin Converting Enzyme-1 and Angiotensin II Blood Levels and Cognitive Function. J Alzheimers Dis 63:655-664|
Showing the most recent 10 out of 830 publications