The Johns Hopkins Alzheimer's Disease Research Center (JHADRC) is an integrated program of investigators whose overarching goal is to improve understanding of the earliest phases of AD and to expand therapeutic approaches. The overall scientific focus of the JHADRC is on the earliest stages of AD and related disorders in humans and in model systems, through characterizing the earliest clinical and pathophysiological processes in humans, and by identifying cellular and molecular events that contribute to the abnormalities in model systems that capture aspects of the human disorders. We also focus efforts on improving care of patients in the symptomatic phases of disease. We have made substantial progress with these research goals during the current funding cycle (which is described below) and propose to continue and expand this work in the next funding cycle. The Center consists of 5 Cores: (1) the Administrative Core (Core A), (2) the Clinical Core (Core B), (3) the Data Management of Statistics Core (Core C), (4) the Neuropathology Core (Core D), and (5) the Outreach, Recruitment and Education Core (Core E). In this application we are proposing 3 new projects: (1) Project 1, to be led by Dr. Arnold Bakker (Assistant Professor of Psychiatry), will examine alterations in brain connectivity in MCI patients and subjects with subjective memory concerns vs. controls, and their relationship to AD CSF biomarkers. (2) Project 2, to be led by Dr. Philip Wong (Professor of Pathology and Neuroscience), will utilize a new mouse model of AD that closely mimics the human disease (by exhibiting both amyloidosis and tauopathy, and demonstrating neuronal loss) to test the hypothesis that amyloid induces tau aggregation to initiate synaptic dysfunction and promote loss of neurons. (3) Project 3, to be led by Dr. Richard Huganir (Professor and Chair of Neuroscience) will examine the impact of excitatory neurotransmitters and neuronal plasticity on synaptic alterations in the earliest phases of AD.

Public Health Relevance

The Johns Hopkins Alzheimer's Disease Research Center is an integrated program aimed at finding improved treatments for patients with Alzheimer disease and related disorders. Complimentary activities within the center include clinical and basic research studies that incorporate state-of-the art methodologies, and contribute significantly to national programs. We are dedicated to training the next generation of investigators and to reaching out to the community to improve understanding about these diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG005146-32S1
Application #
9105626
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (J1))
Program Officer
Phelps, Creighton H
Project Start
1997-07-15
Project End
2020-03-31
Budget Start
2015-08-01
Budget End
2016-03-31
Support Year
32
Fiscal Year
2015
Total Cost
$200,000
Indirect Cost
$76,543
Name
Johns Hopkins University
Department
Pathology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Fredericks, Carolyn A; Sturm, Virginia E; Brown, Jesse A et al. (2018) Early affective changes and increased connectivity in preclinical Alzheimer's disease. Alzheimers Dement (Amst) 10:471-479
Seddighi, Sahba; Varma, Vijay R; An, Yang et al. (2018) SPARCL1 Accelerates Symptom Onset in Alzheimer's Disease and Influences Brain Structure and Function During Aging. J Alzheimers Dis 61:401-414
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Holingue, Calliope; Wennberg, Alexandra; Berger, Slava et al. (2018) Disturbed sleep and diabetes: A potential nexus of dementia risk. Metabolism 84:85-93
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
van Bergen, Jiri M G; Li, Xu; Quevenco, Frances C et al. (2018) Low cortical iron and high entorhinal cortex volume promote cognitive functioning in the oldest-old. Neurobiol Aging 64:68-75
Kim, Sangjune; Yun, Seung Pil; Lee, Saebom et al. (2018) GBA1 deficiency negatively affects physiological ?-synuclein tetramers and related multimers. Proc Natl Acad Sci U S A 115:798-803
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Hohman, Timothy J; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol 75:989-998

Showing the most recent 10 out of 830 publications