Abstract

The Clinical Core (Core B) is divided into two components: 1) The Patient Registry and 2) Data Management and Analysis Component (DMAC). The proposed ADRC Clinical Core will be built upon an existing volunteer patient registry and DMAC within the University Hospitals of Cleveland Alzheimer Center (UHC AC). The functions of the Patient Registry component are to recruit, diagnose, characterize, and periodically reevaluate patients and control subjects. Additionally, the Patient Registry will coordinate participation in other studies, including Consortium to Establish a Registry for Alzheimer's Disease (CERAD) and to obtain consent from families for autopsy. The functions of the DMAC are to facilitate the collection and computerization of data; to maintain the data base, which will permit merging of subjects' specific data from several sources, and assist investigators in the design and execution of analysis plans. A standardized neurological and neuropsychological evaluation is planned for all subjects as an expansion of our existing assessment. The current data base, implemented on an PDP 11-45 is being moved to a Compaq 386 microcomputer. Computation and statistical assistance is being provided through the Department of Epidemiology and Biostatistics.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG008012-04
Application #
3802734
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Moon, Heehyul; Townsend, Aloen L; Whitlatch, Carol J et al. (2017) Quality of Life for Dementia Caregiving Dyads: Effects of Incongruent Perceptions of Everyday Care and Values. Gerontologist 57:657-666
Moon, Heehyul; Townsend, Aloen L; Dilworth-Anderson, Peggye et al. (2016) Predictors of Discrepancy Between Care Recipients With Mild-to-Moderate Dementia and Their Caregivers on Perceptions of the Care Recipients' Quality of Life. Am J Alzheimers Dis Other Demen 31:508-15
Nagpal, Neha; Heid, Allison R; Zarit, Steven H et al. (2015) Religiosity and quality of life: a dyadic perspective of individuals with dementia and their caregivers. Aging Ment Health 19:500-6
Merritt, Marcellus M; McCallum, T J (2013) Too much of a good thing?: Positive religious coping predicts worse diurnal salivary cortisol patterns for overwhelmed African American female dementia family caregivers. Am J Geriatr Psychiatry 21:46-56
Reamy, Allison M; Kim, Kyungmin; Zarit, Steven H et al. (2013) Values and preferences of individuals with dementia: perceptions of family caregivers over time. Gerontologist 53:293-302
Pirisinu, Laura; Nonno, Romolo; Esposito, Elena et al. (2013) Small ruminant nor98 prions share biochemical features with human gerstmann-sträussler-scheinker disease and variably protease-sensitive prionopathy. PLoS One 8:e66405
Xiao, Xiangzhu; Yuan, Jue; Haïk, Stéphane et al. (2013) Glycoform-selective prion formation in sporadic and familial forms of prion disease. PLoS One 8:e58786
Zarit, Steven H; Lee, Jeong E; Barrineau, Mary J et al. (2013) Fidelity and acceptability of an adaptive intervention for caregivers: an exploratory study. Aging Ment Health 17:197-206
Binoy Mathew, K V; Eapen, Charu; Kumar, P Senthil (2012) Reliability and Concurrent Validity of Dynamic Rotator Stability Test-A Cross Sectional study. Indian J Physiother Occup Ther 6:76-81
Reamy, Allison M; Kim, Kyungmin; Zarit, Steven H et al. (2011) Understanding discrepancy in perceptions of values: individuals with mild to moderate dementia and their family caregivers. Gerontologist 51:473-83

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