In its first four years of existence, our NIA ADRC has developed as a broad based research enterprise with major, local and national impact. Our proposal includes the four required cores: Administrative, Clinical, Neuropathology, Research Training and Information Transfer (RTIT). In addition to our existing Patient Registry and Data Management Analysis Components, our clinical core has grown with the recent competitively funded additions of a Psychopathology Assessment Component and NIA Satellite ADRC. Moreover, we have added an NIA funded Caregiver Core that provides data for clinical and social research on characteristics of the caregivers of our patents. Our RTIT core has expanded with competitive funding and considerable involvement from the local and national Alzheimer's Association. In this new application, six research projects are included. Two basic biological studies involve new, recently recruited senior faculty members in our center: G. Landreth the relationship between amyloid and glia; and K. Herrup on transgenic animal models of Alzheimer's disease (AD). Two other new projects involve C. Gilmore, studying the cognitive basis of visual disturbances in AD and D. Ripich evaluating communication in minority and nonminority caregivers; M. Patterson is leading efforts to characterize the behavioral symptoms of AD and K. Smyth is leading efforts in the use of services of caregivers with strong linkages to our two new cores. Our strong pilot program continues. Of over 50 faculty and other senior investigators involved with our AD research efforts at the University, many were introduced to the field through the pilot program. The renewal pilots as similarly broad in scope as our research projects ranging from basic biology (S. Younkin, amyloid processing) to clinical (J. Fagan, visual attention and K. Smyth, insight and denial of illness). Our proposed expansion of the NIA ADRC will allow us to continue our leadership role in the rapidly advancing national and international efforts to understand AD and improve the quality of lives of its victims.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG008012-08
Application #
2049994
Study Section
Neuroscience, Behavior and Sociology of Aging Review Committee (NBSA)
Project Start
1988-09-21
Project End
1998-05-31
Budget Start
1995-06-01
Budget End
1996-05-31
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Neurology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Moon, Heehyul; Townsend, Aloen L; Whitlatch, Carol J et al. (2017) Quality of Life for Dementia Caregiving Dyads: Effects of Incongruent Perceptions of Everyday Care and Values. Gerontologist 57:657-666
Moon, Heehyul; Townsend, Aloen L; Dilworth-Anderson, Peggye et al. (2016) Predictors of Discrepancy Between Care Recipients With Mild-to-Moderate Dementia and Their Caregivers on Perceptions of the Care Recipients' Quality of Life. Am J Alzheimers Dis Other Demen 31:508-15
Nagpal, Neha; Heid, Allison R; Zarit, Steven H et al. (2015) Religiosity and quality of life: a dyadic perspective of individuals with dementia and their caregivers. Aging Ment Health 19:500-6
Merritt, Marcellus M; McCallum, T J (2013) Too much of a good thing?: Positive religious coping predicts worse diurnal salivary cortisol patterns for overwhelmed African American female dementia family caregivers. Am J Geriatr Psychiatry 21:46-56
Reamy, Allison M; Kim, Kyungmin; Zarit, Steven H et al. (2013) Values and preferences of individuals with dementia: perceptions of family caregivers over time. Gerontologist 53:293-302
Pirisinu, Laura; Nonno, Romolo; Esposito, Elena et al. (2013) Small ruminant nor98 prions share biochemical features with human gerstmann-sträussler-scheinker disease and variably protease-sensitive prionopathy. PLoS One 8:e66405
Xiao, Xiangzhu; Yuan, Jue; Haïk, Stéphane et al. (2013) Glycoform-selective prion formation in sporadic and familial forms of prion disease. PLoS One 8:e58786
Zarit, Steven H; Lee, Jeong E; Barrineau, Mary J et al. (2013) Fidelity and acceptability of an adaptive intervention for caregivers: an exploratory study. Aging Ment Health 17:197-206
Binoy Mathew, K V; Eapen, Charu; Kumar, P Senthil (2012) Reliability and Concurrent Validity of Dynamic Rotator Stability Test-A Cross Sectional study. Indian J Physiother Occup Ther 6:76-81
Reamy, Allison M; Kim, Kyungmin; Zarit, Steven H et al. (2011) Understanding discrepancy in perceptions of values: individuals with mild to moderate dementia and their family caregivers. Gerontologist 51:473-83

Showing the most recent 10 out of 227 publications