The Neuropathology (NP) Core of the UCLA-Alzheimer's Disease Research Center (hereafter ADRC) will perform complete or """"""""brain only"""""""" autopsies on patients enlisted in the Autopsy Program, as well as patients with over neurodegenerative diseases (and appropriate controls) and will sere as a data and tissue/fluid resource for individuals performing innovative research on Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), non-AD dementias, and other scientists interested in neurodegenerative conditions. Brain tissues from appropriate autopsies will be triaged and stored at the time of necropsy in order to optimize their subsequent use of structural and molecular/pharmacologic research. The tissue harvesting method will be one developed during the first eight years of funding of the UCLA Alzheimer's Disease Center (ADC), i.e. materials will be stored frozen, paraformaldehyde fixed (with subsequent embedding in LR White plastic), or in paraffin blocks. Tissue studies in the NP Core will include systematic blocking of fixed brain tissue, routine and specialized silver strains that demonstrate microscopic AD-related lesions (senile plaques and neurofibrillary tangles), and immunohistochemical staining using both commercially available antibodies and antibodies/reagents/probes developed in the NP Core or with collaborating investigators. Thus tissues/fluids provided to investigators will have been carefully and systematically assessed for AD and related disease processes. Information on autopsied patients also will be submitted to, and maintained in, the ADRC Database, ensuring its availability to investigators carrying out either clinical or basic studies. Other general functions of the NP Core will include (a) Interactions with the Clinical Core and Imaging Sub-core to provide tissues for ApoE genotyping and other work, (c) Morphologic/immunohistochemical support of ongoing AD-related (and animal model-based) studies and Project Leaders by direct collaboration or provision of key reagents, (d) Liaison with community pathologists who are called upon to asses autopsy brain tissue from demented patients, (d) Discussion with lay groups of the importance of autopsies on demented patients, and (e) Collaborating with the Education Core to conduct, optimize and assess the didactic value of a monthly dementia- related clinicopathologic conference.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG016570-01S1
Application #
6295670
Study Section
Project Start
1999-08-15
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Petyuk, Vladislav A; Chang, Rui; Ramirez-Restrepo, Manuel et al. (2018) The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target. Brain 141:2721-2739
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin et al. (2018) Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement 14:205-214
Joe, Elizabeth; Medina, Luis D; Ringman, John M et al. (2018) 1H MRS spectroscopy in preclinical autosomal dominant Alzheimer disease. Brain Imaging Behav :
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161

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