The Biostatistics and Database Management Core will provide database and statistical support to the Mayo Alzheimer's Disease Research Center (ADRC) Projects and Cores. To this end, our specific aims are:
Specific Aim 1. To develop and maintain a relational database housing the longitudinal clinical and neuropsychometric data gathered by the Clinical Core.
Specific Aim 2. To provide database support and biostatistical consulting support to the Projects and Cores. Building upon the existing Mayo ADRC relational database structure, database management staff will expand the Clinical Core psychometric and clinical exam database to accommodate new forms introduced by the Clinical Core and new forms mandated by the NIA (the expanded standard clinical data set). Various improvements to our database will be implemented, including a web-based data element dictionary and electronic data audit capabilities. The Clinical Core database will be linked to imaging, genotype, neuropathology, and DNA and plasma inventory databases, and data management staff will support data requests by Core and Project investigators. Biostatisticians will support Core and Project investigators in study design, analysis, and interpretation. The Biostatistics and Database Management Core will provide database support and dedicated time for statistical consulting to all of the Cores and Projects. Sharing of database and statistical personnel will allow us to efficiently support various projects and ensure that biostatistical consultants familiar with Alzheimer's disease and with the details of the Mayo Clinic ADRC are available to Cores and Projects.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG016574-10
Application #
7618222
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
10
Fiscal Year
2008
Total Cost
$171,555
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
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Wennberg, Alexandra M V; Hagen, Clinton E; Machulda, Mary M et al. (2018) The association between peripheral total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 and functional and cognitive outcomes in the Mayo Clinic Study of Aging. Neurobiol Aging 66:68-74
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Kasanuki, Koji; Ross, Owen A; DeTure, Michael A et al. (2018) Relationships between lewy and tau pathologies in 375 consecutive non-Alzheimer's olfactory bulbs. Mov Disord 33:333-334
Levendowski, Daniel J; St Louis, Erik K; Strambi, Luigi Ferini et al. (2018) Comparison of EMG power during sleep from the submental and frontalis muscles. Nat Sci Sleep 10:431-437

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