The goal of this Alzheimer's Disease Research Center (ADRC), (Director: Lindy Harrell, M.D., Ph.D., and Associate Directors Daniel Marson, J.D., Ph.D., Michael Wyss, M.D.) is to foster a model of clinical and basic science research effect into the pathology of Alzheimer's Disease (AD). This ADRC is comprised of 5 cores and 4 """"""""R01"""""""" type projects. The Administrative ore will provide the implementation of all visibility through pilot grants (i.e., bring new investigators), and a monthly seminar series and interactions with other ADRC/ADCC. The Clinical Core will recruit and annually follow mild and moderate AD patients and normal controls, diagnosed by 2 neurologists (subjects 25% African- American, 75% white, the racial mixture of Jefferson County), will provide 1) biostatistical services, 2) tissue collection, and 3) patients for investigators. Neuropsychological battery, provide additional neuropsychological tests requested by investigators, and develop methods to analyze longitudinal data. Neuropathological Core will obtain diagnoses, process and store tissue (brain, CSF), making these available to investigators. Information Transfer Core will provide education to physicians, lay and paraprofessional communities (with emphasis on African-Americans), maintained a Speakers Bureau, caregiver's newsletter, packets of AD information, add a 1-800 telephone line, continue our annual CME conferences, add a home page on the World Web, and disseminate ADRC research through multimedia means. The first three """"""""R01"""""""" projects are thematically linked to understanding how AD patients lose specific capacities. Project 1 will examine performance of AD patients in a driving stimulator to understand the cognitive changes associated with defective driving and the changes over time. Project 2 will examine behavioral problems impacting caregivers to determine if telephone interventions modify their burden. Project 3 will examine the longitudinal loss of financial capabilities and their neuropsychological underpinnings. Project 4 differs in that the effects of neuregulins (which may regulate Na+, k+ channels and neurotrophins) will be accessed in AD and aging. The Administration strongly supports this ADRC both philosophically and financially, paying full salary (approximately $46,000) of the Administrator, and renovating Brain Resource Program space ($200,000-250,000). An ADRC at UAB would allow us to continue both our clinical and basic science research efforts in AD and would allow us to expand into new research areas.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
1P50AG016582-01
Application #
2802791
Study Section
Special Emphasis Panel (ZAG1-BJS-3 (J5))
Project Start
1999-04-01
Project End
2004-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Neurology
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Lassen-Greene, Caroline L; Steward, Kayla; Okonkwo, Ozioma et al. (2017) Mild Cognitive Impairment and Changes in Everyday Function Over Time: The Importance of Evaluating Both Speed and Accuracy. J Geriatr Psychiatry Neurol 30:220-227
Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384
Niccolai, Lindsay M; Triebel, Kristen L; Gerstenecker, Adam et al. (2017) Neurocognitive Predictors of Declining Financial Capacity in Persons with Mild Cognitive Impairment. Clin Gerontol 40:14-23
Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738
Karch, Celeste M; Ezerskiy, Lubov A; Bertelsen, Sarah et al. (2016) Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One 11:e0148717
Mez, Jesse; Mukherjee, Shubhabrata; Thornton, Timothy et al. (2016) The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiol Aging 41:115-121
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-200.e20
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150
Jun, G; Ibrahim-Verbaas, C A; Vronskaya, M et al. (2016) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry 21:108-17
Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43

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