The overarching goal of the Clinical Core is to provide well-characterized patients and controls for dementia research. This Core will recruit, evaluate, and maintain several research cohorts, including Alzheimer's disease (100), frontotemporal lobar degeneration (75), frontotemporal lobar degeneration with motor neuron disease (10), corticobasal degeneration and progressive supranuclear palsy (30), Creutzfeldt-Jakob disease (20), mild cognitive impairment (100), and healthy elderly controls (100). In addition, as part of a larger minority outreach effort, we will recruit and maintain a cohort of 100 Chinese-Americans (50 cognitively impaired, 50 controls). Each subject will receive state-of-the-art clinical assessments. These will include quantitative neurological examinations and clinical histories, functional assessments, evaluation of memory, language, executive function and other cognitive skills, social/personality function, neurobehavior, and functional abilities. Blood will be drawn in order to bank serum, DNA and cell lines. Subjects will be referred to the imaging Core. Subjects will be carefuUy followed longitudinally, with most components of the evaluation repeated annually. In conjunction with the Data Management and Statistics Core, subject data will be made available to researcher for hypothesis testing, subjects will be selected for enrollment into the ADRC RO1s, pilot studies, and other projects, and referrals to the Neuropathology Core will be facilitated.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG023501-04
Application #
7407532
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
4
Fiscal Year
2007
Total Cost
$283,102
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Casaletto, Kaitlin B; Staffaroni, Adam M; Elahi, Fanny et al. (2018) Perceived Stress is Associated with Accelerated Monocyte/Macrophage Aging Trajectories in Clinically Normal Adults. Am J Geriatr Psychiatry 26:952-963
Orr, Anna G; Lo, Iris; Schumacher, Heike et al. (2018) Istradefylline reduces memory deficits in aging mice with amyloid pathology. Neurobiol Dis 110:29-36
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Watson, Christa L; Possin, Katherine; Allen, I Elaine et al. (2018) Visuospatial Functioning in the Primary Progressive Aphasias. J Int Neuropsychol Soc 24:259-268
Casaletto, K B; Elahi, F M; Fitch, R et al. (2018) A comparison of biofluid cytokine markers across platform technologies: Correspondence or divergence? Cytokine 111:481-489
Tan, Chin Hong; Fan, Chun Chieh; Mormino, Elizabeth C et al. (2018) Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol 135:85-93
Mok, Sue-Ann; Condello, Carlo; Freilich, Rebecca et al. (2018) Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nat Struct Mol Biol 25:384-393

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