The Emory Alzheimer's Disease Center (ADC) provides Georgia and surrounding states with outstanding clinical, research, and educational programs. The ADC emphasis on mild cognitive impairment (MCI) is influenced by shared interests in: i) multi-cultural issues in dementia; ii) the clinical spectrum of MCI; and iii) the role of sleep disorders in neurodegeneration. The ADC Cores (Clinical, Neuropathology, Education,also Data Management) build on renowned clinical programs and cutting-edge research. Convergent local developments bring remarkable growth to the ADC, including: one of the nation's fastest growing research enterprises; new leadership focused on neurodegeneration in the Department of Neurology, Center for Neurodegenerative Disease, and Yerkes National Primate Center; outstanding institutional support; close collaborations with the Emory-NIEHS Parkinson's Disease Center and the Center for Health in Aging; a unique industry partnership with deCODE Genetics to discover new susceptibility genes; outstanding clinical programs with a large and diverse patient populations at Wesley Woods Center and Grady Memorial Hospital, with the latter providing services and research opportunities for a predominantly African-American population; and a partnership with Dr. Bernardino Ghetti (Indiana ADC) to jointly operate the Neuropathology Core and enhance research at both institutions. Three cutting edge research projects are closely integrated with ADC Cores: Project 1 (Dr. Stuart Zola) adapts novel, highly sensitive memory tasks developed in non-human primates to ADC Clinical Core subjects; Project 2 (Dr. Allan Levey) tests the association of novel candidate genes for AD and PD, discovered in Iceland, in ADC Clinical Core subjects; and Project 3 (Dr. Junmin Peng) applies state-of-the-art proteomics technologies to MCI, AD, and PD brains characterized in the Neuropathology Core. Collectively, these projects span clinical, translational, and basic research and will advance our understanding of MCI, AD, PD, and related disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG025688-01S1
Application #
7121378
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Phelps, Creighton H
Project Start
2005-06-01
Project End
2010-04-30
Budget Start
2005-09-30
Budget End
2006-04-30
Support Year
1
Fiscal Year
2005
Total Cost
$38,639
Indirect Cost
Name
Emory University
Department
Neurology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
He, Yingli; She, Hua; Zhang, Ting et al. (2018) p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1. J Cell Biol 217:315-328
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Hampstead, Benjamin M; Towler, Stephen; Stringer, Anthony Y et al. (2018) Continuous measurement of object location memory is sensitive to effects of age and mild cognitive impairment and related to medial temporal lobe volume. Alzheimers Dement (Amst) 10:76-85
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Kaur, Gurjinder; Gauthier, Sebastien A; Perez-Gonzalez, Rocio et al. (2018) Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome. Neurobiol Dis 120:165-173
Walker, Lary C (2018) Sabotage by the brain's supporting cells helps fuel neurodegeneration. Nature 557:499-500
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Ping, Lingyan; Duong, Duc M; Yin, Luming et al. (2018) Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's Disease. Sci Data 5:180036

Showing the most recent 10 out of 444 publications