The objectives of the Data Management and Statistics (DMS) Core is to provide the data management and statistical expertise that is vital to the orderiy progress and success ofthe research projects and ancillary studies of the Emory University Alzheimer's Disease Research Center (ADRC). The DSM Core will be responsible for the following activities related to the ADRC:
Aim 1. To provide, manage and maintain a high-quality research database that supports the research projects, cores, and ancillary studies of the Emory University ADRC;to cooperate with the Clinical Core in the human subjects protection administration for research subjects;to implement technological and practical policies and procedures to preserve the confidentiality of all patient and control subject records;oversee and manage the collection of data for research projects conducted by Emory investigators working with the ADRC.
Aim 2. To provide statistical consulting and collaboration on the design, conduct, analysis and interpretation of ADRC research studies.
Aim 3. To cooperate with and share Uniform Data Set (UDS) data with the National Alzheimer's Coordinating Center (NACC). We have developed a data entry system and a manual of standard operating procedures for this system which allows secure and valid data entry for both UDS data and data on all neurology patients. We plan to move to Web-based data entry in collaboration with other ADRCs, via adoption of a system developed by the UCSF ADRC. We have in place a system to provide research subjects and data to ADRC investigators in a manner that protects patients'confidentiality and complies with Emory IRB guidelines. We coordinate closely with other cores, in particular the Clinical and Neuropathology cores. We provide statistical and epidemiologic support to ADRC projects and investigators via two statisticians and one epidemiologist who are part of the core. Furthermore, core personnel conduct their own research, which has led to past publications and which will continue in the new grant period.

Public Health Relevance

The Data Management and Statistics Core is an essential component ofthe ADRC, enabling us to comply with NACC's requirement for UDS subjects, to rapidly transmit needed data to ADRC investigators in a secure fashion protecting patient confidentiality, to provide statistical help to ADRC investigators, and to develop new statistical techniques which will be of use to the field in general.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (J2))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
United States
Zip Code
Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Zhou, Zilu; Wang, Weixin; Wang, Li-San et al. (2018) Integrative DNA copy number detection and genotyping from sequencing and array-based platforms. Bioinformatics 34:2349-2355
Rangaraju, Srikant; Raza, Syed Ali; Li, Noel Xiang'An et al. (2018) Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes-Activation and Age-Related Effects. Front Immunol 9:405
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Chalermpalanupap, Termpanit; Schroeder, Jason P; Rorabaugh, Jacki M et al. (2018) Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice. J Neurosci 38:74-92
Maezawa, Izumi; Nguyen, Hai M; Di Lucente, Jacopo et al. (2018) Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain 141:596-612
Bishof, Isaac; Dammer, Eric B; Duong, Duc M et al. (2018) RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease. J Biol Chem 293:11047-11066
Peng, Katherine Y; Pérez-González, Rocío; Alldred, Melissa J et al. (2018) Apolipoprotein E4 genotype compromises brain exosome production. Brain :

Showing the most recent 10 out of 444 publications