It is expected that a number of researchers in the ADRC will be involved with, or wish to become involved with, behavioral and/or histopathologic studies in genetically-manipulated mouse models for AD. The Mouse Behavior and Neuropathology (MBN) core is the central core through which such studies will be designed and performed at the ADRC, utilizing equipment and expertise of the MBN Core. Thus, the main function of the MBN Core will be to acquaint other Pi's and their laboratory personnel with the collection and analysis of behavioral/histopathologic data, as well as provide expertise in the interpretation of results obtained. Specifically, the MBN Core will 1) design and carry out behavioral/histopathologic studies in geneticallymanipulated mouse models of AD that involve MBN Core personnel 2) assist other ADRC researchers in designing and carrying out mouse behavioral/histopathologic studies that relate to the research questions they are addressing 3) provide training and consultation in behavioral and histopathologic methodologies to ADRC researchers, and those utilizing ADRC resources, so that they may incorporate such methodologies into their research and utilize these methodologies independently within the MBN Core facilities, and 4) provide behavioral and histopathologic data to the Data Management, Biostatistics, and Epidemiology (DMBE) Core from projects and studies performed within the MBN Core. The DMBE will then store/analyze these data, determine any correlations/inter-relationships between behavioral and histopathologic data in any given study, and provide any interfacing statistical analyses between MBN data (e.g., Project #3) and that attained from related clinical projects (e.g., Project #2). The work of this Core is absolutely essential for investigating Alzheimer's disease mechanisms, genetics, risk factors and treatments in the context of this ADRC proposal.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
1P50AG025711-01
Application #
6932233
Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (J4))
Project Start
2005-04-01
Project End
2010-03-30
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
1
Fiscal Year
2005
Total Cost
$48,012
Indirect Cost
Name
University of South Florida
Department
Type
DUNS #
069687242
City
Tampa
State
FL
Country
United States
Zip Code
33612
Beer, Joanne C; Snitz, Beth E; Chang, Chung-Chou H et al. (2018) Does a cognitive stress test predict progression from mild cognitive impairment to dementia equally well in clinical versus population-based settings? Int Psychogeriatr 30:1435-1445
Burke, Shanna L; Rodriguez, Miriam J; Barker, Warren et al. (2018) Relationship between Cognitive Performance and Measures of Neurodegeneration among Hispanic and White Non-Hispanic Individuals with Normal Cognition, Mild Cognitive Impairment, and Dementia. J Int Neuropsychol Soc 24:176-187
Li, Zeran; Del-Aguila, Jorge L; Dube, Umber et al. (2018) Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure. Genome Med 10:43
Sun, Wenyan; Samimi, Hanie; Gamez, Maria et al. (2018) Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nat Neurosci 21:1038-1048
Caneus, Julbert; Granic, Antoneta; Rademakers, Rosa et al. (2018) Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations. Mol Biol Cell 29:575-586
Kidana, Kiwami; Tatebe, Takuya; Ito, Kaori et al. (2018) Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. EMBO Mol Med 10:
Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384
Carrasquillo, Minerva M; Allen, Mariet; Burgess, Jeremy D et al. (2017) A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression. Alzheimers Dement 13:663-673
Miller, Jeremy A; Guillozet-Bongaarts, Angela; Gibbons, Laura E et al. (2017) Neuropathological and transcriptomic characteristics of the aged brain. Elife 6:
Carrasquillo, Minerva M; Barber, Imelda; Lincoln, Sarah J et al. (2016) Evaluating pathogenic dementia variants in posterior cortical atrophy. Neurobiol Aging 37:38-44

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