A major focus of the Wisconsin ADRC research agenda is multi-disciplinary translational neuroscience in humans with evidence of AD pathology with or without clinical features. In-vivo neuroimaging assessments, including new tau and amyloid imaging, and sophisticated analytic techniques are increasingly being utilized or sought by our investigators to gain further insights about the neurobiology of AD. The NeuroImaging Core was created to provide necessary infrastructure and resources for investigators to successfully implement imaging outcomes in an efficient manner. The Core reduces duplication of effort and resources, while at the same time maximizing the possibilities of collaboration and the leveraging of data across ADRC affiliated projects through standardization of select scan modalities/sequences. The Core has experienced extensive utilization and growth that exceeded projections resulting in support for over 45 funded projects, the majority were funded federally. This occurred largely by emphasizing support of new faculty and faculty who were not imaging experts per se, but nevertheless desired to enhance the significance and impact of their studies by incorporating state of the art imaging outcomes. The Core now proposes to add [F18]THK5351 tau imaging and [C11]PiB amyloid PET imaging for 300 participants. The original Specific Aims are: 1) To provide imaging support for the ADRC cohorts (MRI) and support the imaging needs in Project 2. 2) To provide imaging informatics support for ADRC-affiliated projects including tools for cataloging and interacting with imaging data in a project specific manner. 3) Make available the latest advanced PET and MRI imaging methods and data analysis capabilities to ADRC affiliated projects. 4) Provide training to investigators and staff in the ADRC and University at large on neuroimaging methods and analysis techniques pertaining to neuro-disorders. We also provide pre- and post-award consultation to investigators who are implementing/planning imaging studies, and assist in grant preparation, study design, and startup. The major goals of this supplemental proposal are to 1) Describe the spatial patterns of tau and amyloid across stages of AD, and identify those spatial pre- dementia disease profiles most associated with subsequent decline. 2) Determine the concordance between CSF metrics of AD pathology and tau and amyloid imaging. 3) To completely integrate amyloid and tau imaging information into our center's infrastructure, process, and data sharing initiatives. This award will significantly enhance the overall impact of the center by establishing crucial tau and amyloid molecular imaging endophenotypes. The field has suffered from a lack of clarity on preclinical AD, because we have not had the tools to spatially characterize amyloid plaque and NFTs. This project represents a unique opportunity to examine the earliest determinants of AD progression, which is a central scientific theme of the Wisconsin ADRC. The unique data collected will be made available immediately to the research community.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG033514-10S1
Application #
9209025
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
10
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Johnson, Sterling C; Koscik, Rebecca L; Jonaitis, Erin M et al. (2018) The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions. Alzheimers Dement (Amst) 10:130-142
Dougherty, Ryan J; Lindheimer, Jacob B; Stegner, Aaron J et al. (2018) An Objective Method to Accurately Measure Cardiorespiratory Fitness in Older Adults Who Cannot Satisfy Widely Used Oxygen Consumption Criteria. J Alzheimers Dis 61:601-611
Dempsey, Robert J; Varghese, Tomy; Jackson, Daren C et al. (2018) Carotid atherosclerotic plaque instability and cognition determined by ultrasound-measured plaque strain in asymptomatic patients with significant stenosis. J Neurosurg 128:111-119
Besser, Lilah; Kukull, Walter; Knopman, David S et al. (2018) Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set. Alzheimer Dis Assoc Disord 32:351-358
Pozorski, Vincent; Oh, Jennifer M; Adluru, Nagesh et al. (2018) Longitudinal white matter microstructural change in Parkinson's disease. Hum Brain Mapp 39:4150-4161
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Holden, Timothy R; Keller, Sarah; Kim, Alice et al. (2018) Procedural Framework to Facilitate Hospital-Based Informed Consent for Dementia Research. J Am Geriatr Soc 66:2243-2248

Showing the most recent 10 out of 374 publications