Finding effective treatments and preventative therapies for Alzheimer's disease (AD) is one of the country's most serious unmet medical needs. With ~500,000 AD patients and >3 million at-risk individuals over age 65, Florida is an epicenter of the AD epidemic in the United States; yet, there are no active ADRCs or ADCCs primarily based in the State. In order to further our collective understanding of AD and related dementias, the University of Florida (UF)-Mount Sinai Medical Center (MSMC) AD Research Center (ADRC) will coalesce research efforts within the Wien Memory Disorder Center at MSMC in Miami and the UF in Gainesville. These efforts will capitalize on the clinical population in the Wien Center that is majority Hispanic, the expansive research capabilities at UF, and the infrastructure for translational research provided by the NIH funded UF Clinical and Translational Science Institute. Major goals of the UF-MSMC ADRC are to; i) further elucidate the correlation of early cognitive impairment to various biomarkers of brain structure and function; ii) understand predictors of decline in Hispanic and Non-Hispanic individuals; iii) support translational research efforts that will further the understanding of disease mechanisms; iv) lay the groundwork for improved designs for testing novel therapies for AD and related dementias, and; v) have a broad state-wide educational impact including recruitment of junior investigators into the AD field. In addition to the five required Cores, three Projects are proposed. Project I explores the hypothesis that MRI-based measures of free water can provide important theragnostic information in AD. Project II evaluates new cognitive paradigms that will be more sensitive to the earliest manifestations of AD in Hispanic and non-Hispanic populations. Project III will develop new models of mixed AD pathologies and evaluate immunotherapeutic approaches aimed at modifying these mixed pathologies. Having recognized the need for ADRCs in Florida, there is substantial multi-institutional support for this ADRC and, importantly, supplemental State of Florida legislative funding.

Public Health Relevance

Florida is an epicenter of the Alzheimer's disease (AD) epidemic in the US. Given the burden of AD in Florida, the state should be a leader, not a bystander, in the fight to cure AD by 2025. The UF-MSMC ADRC proposal will create infrastructure that supports research and educational activities as well as clinical care for patients with AD and other dementias. It will also serve as a hub for translational work that is needed to advance the science in order to reach our shared goal of treating and preventing AD.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
1P50AG047266-01A1
Application #
8848980
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Phelps, Creighton H
Project Start
2015-08-15
Project End
2020-05-31
Budget Start
2015-08-15
Budget End
2016-05-31
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Florida
Department
Neurosciences
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Burke, Shanna L; Rodriguez, Miriam J; Barker, Warren et al. (2018) Relationship between Cognitive Performance and Measures of Neurodegeneration among Hispanic and White Non-Hispanic Individuals with Normal Cognition, Mild Cognitive Impairment, and Dementia. J Int Neuropsychol Soc 24:176-187
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Striley, Catherine W; Milani, Sadaf A; Kwiatkowski, Evan et al. (2018) Community perceptions related to brain donation: Evidence for intervention. Alzheimers Dement :
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679

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